Yohanis Alemeshet Asefa, Lars Åke Persson, Anna C Seale, Nega Assefa
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To the best of our knowledge, reviews have previously focused on the burden of perinatal deaths; here we aim to synthesize evidence on the burden, causes, and risk factors for perinatal mortality in East Africa.</p><p><strong>Methods: </strong>We will conduct a systematic literature search in Medline, Web of Science, EMBASE, Global Health, SCOPUS, Cochrane Library, CINAHL, HINARI, African Index Medicus, African Journals Online (AJOL), and WHO African Regional Office (AFRO) Library. The study population includes all fetuses and newborns from ≥22 weeks of gestation (birth weight ≥500gm) to 7 days after birth, with reported causes or/and determinants as exposure, and perinatal mortality (stillbirths and/or early neonatal deaths) as an outcome. We will include studies from 2010 to 2022, and to facilitate the inclusion of up-to-date data, we will request recent data from ongoing surveillance in the region. 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引用次数: 0
摘要
背景：尽管全球 5 岁以下儿童死亡率在过去 30 年中大幅下降，但每年仍有约 260 万死胎和 290 万新生儿死亡。这些死亡大多发生在非洲和南亚。要减少东非的围产期死亡，了解围产期死亡的负担、风险因素和原因至关重要。据我们所知，以前的综述主要集中在围产期死亡的负担方面；在此，我们旨在综合东非围产期死亡的负担、原因和风险因素方面的证据：我们将在 Medline、Web of Science、EMBASE、Global Health、SCOPUS、Cochrane Library、CINAHL、HINARI、African Index Medicus、African Journals Online (AJOL) 和 WHO African Regional Office (AFRO) Library 中进行系统的文献检索。研究对象包括妊娠≥22周（出生体重≥500gm）至出生后7天的所有胎儿和新生儿，以报告的原因或/和决定因素作为暴露，围产期死亡率（死胎和/或新生儿早期死亡）作为结果。我们将纳入 2010 年至 2022 年的研究，为便于纳入最新数据，我们将要求提供该地区持续监测的最新数据。为了评估所纳入研究的质量，我们将使用乔安娜-布里格斯研究所（Joanna Briggs Institute）的观察性和试验性研究质量评估工具。我们将使用 STATA 17 版统计软件分析数据，并分别通过 Higgins' I 2 和漏斗图评估异质性和发表偏倚：本系统综述将搜索有关东非围产期死亡率的负担、原因和风险因素的已发表研究，并寻求未发表的数据。将报告研究结果，找出证据基础中的差距，并提出建议，最终目的是减少围产期死亡：PROSPERO-CRD42021291719.
Burden, causes, and risk factors of perinatal mortality in Eastern Africa: a protocol for systematic review and meta-analysis.
Background: Although global mortality rates in children under 5 years have decreased substantially in the last 30 years, there remain around 2.6 million stillbirths and 2.9 million neonatal deaths each year. The majority of these deaths occur in Africa and South Asia. To reduce perinatal deaths in East Africa, knowledge of the burden, but also the risk factors and causes of perinatal deaths are crucial. To the best of our knowledge, reviews have previously focused on the burden of perinatal deaths; here we aim to synthesize evidence on the burden, causes, and risk factors for perinatal mortality in East Africa.
Methods: We will conduct a systematic literature search in Medline, Web of Science, EMBASE, Global Health, SCOPUS, Cochrane Library, CINAHL, HINARI, African Index Medicus, African Journals Online (AJOL), and WHO African Regional Office (AFRO) Library. The study population includes all fetuses and newborns from ≥22 weeks of gestation (birth weight ≥500gm) to 7 days after birth, with reported causes or/and determinants as exposure, and perinatal mortality (stillbirths and/or early neonatal deaths) as an outcome. We will include studies from 2010 to 2022, and to facilitate the inclusion of up-to-date data, we will request recent data from ongoing surveillance in the region. To assess the quality of included studies, we will use the Joanna Briggs Institute quality assessment tool for observational and trial studies. We will analyze the data using STATA version 17 statistical software and assess heterogeneity and publication bias by Higgins' I 2 and funnel plot, respectively.
Conclusions: This systematic review will search for published studies, and seek unpublished data, on the burden, causes, and risk factors of perinatal mortality in East Africa. Findings will be reported, and gaps in the evidence base identified, with recommendations, with the ultimate aim of reducing perinatal deaths.
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