MONICA L. RUIZ, RITA A. GOMEZ-DIAZ, ADRIANA LETICIA VALDEZ GONZALEZ, SELENE ÁNGELES MEJÍA, MARGARITA DIAZ-FLORES, RICARDO C. SALDAÑA ESPINOZA, MARY F. DÍAZ, LUZ ANGELICA RAMIREZ GARCIA, NIELS H. WACHER
{"title":"1248-P: 氧化应激标记物与妊娠期糖尿病高血糖的关系--糖尿病预防计划的影响","authors":"MONICA L. RUIZ, RITA A. GOMEZ-DIAZ, ADRIANA LETICIA VALDEZ GONZALEZ, SELENE ÁNGELES MEJÍA, MARGARITA DIAZ-FLORES, RICARDO C. SALDAÑA ESPINOZA, MARY F. DÍAZ, LUZ ANGELICA RAMIREZ GARCIA, NIELS H. WACHER","doi":"10.2337/db24-1248-p","DOIUrl":null,"url":null,"abstract":"Introduction & Objective: Gestational Diabetes (GDM) poses risk for developing type 2 diabetes (T2D). The role of oxidative stress in GDM and its association with incident diabetes remains unclear. This study aimed to assess the link between oxidative stress markers and incident hyperglycemia in women with and without GDM. Methods: Prospective cohort. Pregnant women with GDM (n=201) or without GDM (n=50) undergoing cesarean section participated in an 18-month postpartum prevention program. The program emphasized healthy practices, physical activity, and psychosocial support. Oxidative stress markers [malondialdehyde (MDA), reduced glutathione (GSH), antioxidant capacity (DPPH), carbonylated proteins], and adiponectin were measured at the end of pregnancy and at 18 months later. A control group (CG) (n=57) received standard care. Multiple linear regression identified intervention-related differences. Results: Baseline GDM women exhibited elevated oxidative stress markers and adiponectin compared to non-GDM counterparts. Antioxidant capacity was lower in GDM (40 vs. 67.8%, p=<0.001). Post-intervention, GDM cases showed a greater reduction in MDA and adiponectin (-37.55 vs-34.08 nmol, p=0.021; -751.54 vs-210.31 pg/mL, p<0.001 respectively) and antioxidant capacity increased (in both groups: 1.0 - 0.28%, vs CG -7.23 p=0.009). At follow-up, 6% progressed to T2D, and 37.3% to prediabetes. Basal malondialdehyde concentrations, pregestational BMI, and HbA1c positively correlated with incident hyperglycemia. Conversely, the change in carbonylated proteins concentrations inversely correlated with incident hyperglycemia. Conclusion: Oxidative markers are associated with T2D risk in GDM. The diabetes prevention program effectively reduced malondialdehyde and adiponectin levels. These findings highlight the role of oxidative stress in GDM prevention strategies. Disclosure M.L. Ruiz: None. R.A. Gomez-Diaz: None. A. Valdez Gonzalez: None. S. Ángeles Mejía: None. M. Diaz-Flores: None. R.C. Saldaña Espinoza: None. M.F. Díaz: None. L. Ramirez Garcia: None. N.H. Wacher: None. Funding Fundación Gonzalo Río Arronte, Institution of Private Assistance (S.0634), and the Coordinación de Investigación en Salud (R2022-785-057)","PeriodicalId":11376,"journal":{"name":"Diabetes","volume":null,"pages":null},"PeriodicalIF":6.2000,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"1248-P: Association of Oxidative Stress Markers with Incident Hyperglycemia in Gestational Diabetes Mellitus—Impact of a Diabetes Prevention Program\",\"authors\":\"MONICA L. RUIZ, RITA A. GOMEZ-DIAZ, ADRIANA LETICIA VALDEZ GONZALEZ, SELENE ÁNGELES MEJÍA, MARGARITA DIAZ-FLORES, RICARDO C. SALDAÑA ESPINOZA, MARY F. DÍAZ, LUZ ANGELICA RAMIREZ GARCIA, NIELS H. WACHER\",\"doi\":\"10.2337/db24-1248-p\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Introduction & Objective: Gestational Diabetes (GDM) poses risk for developing type 2 diabetes (T2D). The role of oxidative stress in GDM and its association with incident diabetes remains unclear. This study aimed to assess the link between oxidative stress markers and incident hyperglycemia in women with and without GDM. Methods: Prospective cohort. Pregnant women with GDM (n=201) or without GDM (n=50) undergoing cesarean section participated in an 18-month postpartum prevention program. The program emphasized healthy practices, physical activity, and psychosocial support. Oxidative stress markers [malondialdehyde (MDA), reduced glutathione (GSH), antioxidant capacity (DPPH), carbonylated proteins], and adiponectin were measured at the end of pregnancy and at 18 months later. A control group (CG) (n=57) received standard care. Multiple linear regression identified intervention-related differences. Results: Baseline GDM women exhibited elevated oxidative stress markers and adiponectin compared to non-GDM counterparts. Antioxidant capacity was lower in GDM (40 vs. 67.8%, p=<0.001). Post-intervention, GDM cases showed a greater reduction in MDA and adiponectin (-37.55 vs-34.08 nmol, p=0.021; -751.54 vs-210.31 pg/mL, p<0.001 respectively) and antioxidant capacity increased (in both groups: 1.0 - 0.28%, vs CG -7.23 p=0.009). At follow-up, 6% progressed to T2D, and 37.3% to prediabetes. Basal malondialdehyde concentrations, pregestational BMI, and HbA1c positively correlated with incident hyperglycemia. Conversely, the change in carbonylated proteins concentrations inversely correlated with incident hyperglycemia. Conclusion: Oxidative markers are associated with T2D risk in GDM. The diabetes prevention program effectively reduced malondialdehyde and adiponectin levels. These findings highlight the role of oxidative stress in GDM prevention strategies. Disclosure M.L. Ruiz: None. R.A. Gomez-Diaz: None. A. Valdez Gonzalez: None. S. Ángeles Mejía: None. M. Diaz-Flores: None. R.C. Saldaña Espinoza: None. M.F. Díaz: None. L. Ramirez Garcia: None. N.H. Wacher: None. 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1248-P: Association of Oxidative Stress Markers with Incident Hyperglycemia in Gestational Diabetes Mellitus—Impact of a Diabetes Prevention Program
Introduction & Objective: Gestational Diabetes (GDM) poses risk for developing type 2 diabetes (T2D). The role of oxidative stress in GDM and its association with incident diabetes remains unclear. This study aimed to assess the link between oxidative stress markers and incident hyperglycemia in women with and without GDM. Methods: Prospective cohort. Pregnant women with GDM (n=201) or without GDM (n=50) undergoing cesarean section participated in an 18-month postpartum prevention program. The program emphasized healthy practices, physical activity, and psychosocial support. Oxidative stress markers [malondialdehyde (MDA), reduced glutathione (GSH), antioxidant capacity (DPPH), carbonylated proteins], and adiponectin were measured at the end of pregnancy and at 18 months later. A control group (CG) (n=57) received standard care. Multiple linear regression identified intervention-related differences. Results: Baseline GDM women exhibited elevated oxidative stress markers and adiponectin compared to non-GDM counterparts. Antioxidant capacity was lower in GDM (40 vs. 67.8%, p=<0.001). Post-intervention, GDM cases showed a greater reduction in MDA and adiponectin (-37.55 vs-34.08 nmol, p=0.021; -751.54 vs-210.31 pg/mL, p<0.001 respectively) and antioxidant capacity increased (in both groups: 1.0 - 0.28%, vs CG -7.23 p=0.009). At follow-up, 6% progressed to T2D, and 37.3% to prediabetes. Basal malondialdehyde concentrations, pregestational BMI, and HbA1c positively correlated with incident hyperglycemia. Conversely, the change in carbonylated proteins concentrations inversely correlated with incident hyperglycemia. Conclusion: Oxidative markers are associated with T2D risk in GDM. The diabetes prevention program effectively reduced malondialdehyde and adiponectin levels. These findings highlight the role of oxidative stress in GDM prevention strategies. Disclosure M.L. Ruiz: None. R.A. Gomez-Diaz: None. A. Valdez Gonzalez: None. S. Ángeles Mejía: None. M. Diaz-Flores: None. R.C. Saldaña Espinoza: None. M.F. Díaz: None. L. Ramirez Garcia: None. N.H. Wacher: None. Funding Fundación Gonzalo Río Arronte, Institution of Private Assistance (S.0634), and the Coordinación de Investigación en Salud (R2022-785-057)
期刊介绍:
Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes.
However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.