淋巴周围调节性 T 细胞-树突状细胞相互作用是癌症免疫抑制的新轴心

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-07-18 DOI:10.1016/j.ccell.2024.06.016

引用次数: 0

摘要

树突状细胞是适应性抗肿瘤免疫的关键诱导因子。然而，在肿瘤微环境中，树突状细胞的成熟、活化和迁移往往受到损害。在本期杂志中，You 等人展示了树突状细胞功能的一种新的抑制轴，它是通过与淋巴周围龛中的调节性 T 细胞相互作用而介导的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Perilymphatic regulatory T cell-dendritic cell interactions represent a novel axis of immunosuppression in cancer

Dendritic cells are critical inducers of adaptive anti-tumor immunity. However, their maturation, activation, and migration are often compromised in the tumor microenvironment. In this issue, You et al. demonstrate a novel axis of suppression of dendritic cell function mediated by interaction with regulatory T cells in perilymphatic niches.

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.