Anas Elgenidy, Mohammed Al-Mahdi Al-Kurdi, Hoda Atef Abdelsattar Ibrahim, Eman F Gad, Ahmed K Awad, Rebecca Caruana, Sheriseane Diacono, Aya Sherif, Tasneem Elattar, Islam E Al-Ghanam, Asmaa M Eldmaty, Tareq M Abubasheer, Ahmed M Afifi, Amira Elhoufey, Hamad Ghaleb Dailah, Amira M Osman, Mohamed Ezzat, Doaa Ali Gamal, Rady Elmonier, Ahmed El-Sayed Hammour, Maged T Abougabal, Khaled Saad
{"title":"通过登记分析了解急性髓性白血病的死亡原因：儿童、青少年和青年患者的回顾性队列研究》。","authors":"Anas Elgenidy, Mohammed Al-Mahdi Al-Kurdi, Hoda Atef Abdelsattar Ibrahim, Eman F Gad, Ahmed K Awad, Rebecca Caruana, Sheriseane Diacono, Aya Sherif, Tasneem Elattar, Islam E Al-Ghanam, Asmaa M Eldmaty, Tareq M Abubasheer, Ahmed M Afifi, Amira Elhoufey, Hamad Ghaleb Dailah, Amira M Osman, Mohamed Ezzat, Doaa Ali Gamal, Rady Elmonier, Ahmed El-Sayed Hammour, Maged T Abougabal, Khaled Saad","doi":"10.14740/jocmr5205","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Our objective was to identify non-malignant factors that contribute to mortality in children, adolescents and young adults, aiming to improve patient follow-up and reduce mortality rates to achieve better survival outcomes.</p><p><strong>Methods: </strong>We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000 and 2019 in the USA. Using version 8.4.0.1 of the Surveillance, Epidemiology, and End Results (SEER)*Stat software, we calculated the standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) for each cause of death.</p><p><strong>Results: </strong>Out of the 3,165 deaths observed in the study population, the majority (2,245;70.9%) were attributed to AML itself, followed by non-AML cancers (573; 18.1%) and non-cancerous causes (347; 10.9%).</p><p><strong>Conclusions: </strong>Patients with AML are at a higher risk of developing other types of cancer and granulocyte deficiencies, which increases the risk of death from non-cancerous causes such as infections. Moreover, treatment for AML carries the risk of cardiac problems. AML is commoner in males than females.</p>","PeriodicalId":94329,"journal":{"name":"Journal of clinical medicine research","volume":"16 6","pages":"310-318"},"PeriodicalIF":1.6000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254311/pdf/","citationCount":"0","resultStr":"{\"title\":\"Mapping the Grounds for Mortalities in Acute Myeloid Leukemia Through Registry Analyses: A Retrospective Cohort Study of Children, Adolescents, and Young Adults Patients.\",\"authors\":\"Anas Elgenidy, Mohammed Al-Mahdi Al-Kurdi, Hoda Atef Abdelsattar Ibrahim, Eman F Gad, Ahmed K Awad, Rebecca Caruana, Sheriseane Diacono, Aya Sherif, Tasneem Elattar, Islam E Al-Ghanam, Asmaa M Eldmaty, Tareq M Abubasheer, Ahmed M Afifi, Amira Elhoufey, Hamad Ghaleb Dailah, Amira M Osman, Mohamed Ezzat, Doaa Ali Gamal, Rady Elmonier, Ahmed El-Sayed Hammour, Maged T Abougabal, Khaled Saad\",\"doi\":\"10.14740/jocmr5205\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Our objective was to identify non-malignant factors that contribute to mortality in children, adolescents and young adults, aiming to improve patient follow-up and reduce mortality rates to achieve better survival outcomes.</p><p><strong>Methods: </strong>We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000 and 2019 in the USA. Using version 8.4.0.1 of the Surveillance, Epidemiology, and End Results (SEER)*Stat software, we calculated the standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) for each cause of death.</p><p><strong>Results: </strong>Out of the 3,165 deaths observed in the study population, the majority (2,245;70.9%) were attributed to AML itself, followed by non-AML cancers (573; 18.1%) and non-cancerous causes (347; 10.9%).</p><p><strong>Conclusions: </strong>Patients with AML are at a higher risk of developing other types of cancer and granulocyte deficiencies, which increases the risk of death from non-cancerous causes such as infections. Moreover, treatment for AML carries the risk of cardiac problems. AML is commoner in males than females.</p>\",\"PeriodicalId\":94329,\"journal\":{\"name\":\"Journal of clinical medicine research\",\"volume\":\"16 6\",\"pages\":\"310-318\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254311/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of clinical medicine research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.14740/jocmr5205\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/6/30 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of clinical medicine research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14740/jocmr5205","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/6/30 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Mapping the Grounds for Mortalities in Acute Myeloid Leukemia Through Registry Analyses: A Retrospective Cohort Study of Children, Adolescents, and Young Adults Patients.
Background: Our objective was to identify non-malignant factors that contribute to mortality in children, adolescents and young adults, aiming to improve patient follow-up and reduce mortality rates to achieve better survival outcomes.
Methods: We analyzed 8,239 acute myeloid leukemia (AML) cases diagnosed between 2000 and 2019 in the USA. Using version 8.4.0.1 of the Surveillance, Epidemiology, and End Results (SEER)*Stat software, we calculated the standardized mortality ratios (SMRs) and 95% confidence intervals (CIs) for each cause of death.
Results: Out of the 3,165 deaths observed in the study population, the majority (2,245;70.9%) were attributed to AML itself, followed by non-AML cancers (573; 18.1%) and non-cancerous causes (347; 10.9%).
Conclusions: Patients with AML are at a higher risk of developing other types of cancer and granulocyte deficiencies, which increases the risk of death from non-cancerous causes such as infections. Moreover, treatment for AML carries the risk of cardiac problems. AML is commoner in males than females.
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