Aleksandar Denic, Andrew D Rule, Walter D Park, Byron H Smith, Mateo Velasquez Mejia, Aleksandra Kukla, Joseph P Grande, Mark D Stegall
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引用次数: 0
摘要
背景:肾间质纤维化/肾小管萎缩(IFTA)的收缩可能导致IFTA%不能充分反映肾小球丧失的严重程度。IFTA病灶密度较高是预测原生肾脏进展性慢性肾病的重要指标,而与IFTA%无关:我们研究了 2000-2013 年间接受肾移植的受者,他们接受了为期 5 年的肾活检监测和后续随访。我们从病理报告中获得了 Banff ci 评分(间质纤维化)。活组织切片数字化后,我们在单个三色染色切片上追踪皮质面积和每个明显的 IFTA 病灶。计算IFTA面积百分比和IFTA病灶密度(IFTA病灶数/皮质面积)。通过Cox模型评估了5年活检后,以Banff ci评分、形态学%IFTA和IFTA病灶密度为死亡剪除因素的移植物失败风险:结果:在5年的随访中,835名肾脏受者中有58例死亡剪除的异体移植物失败。失败移植物的活检组织具有较高的平均 Banff ci 评分(1.5 vs 0.7,pConclusions):IFTA病灶密度的形态学特征是目前用于肾脏纤维化分级的Banff分级方法中无法捕捉到的、经死亡筛查的同种异体移植物失败的有力预测因素。