铁(III)催化的波瓦洛夫环化法合成嵌有芳基吡咯支架的融合二苯并[b,f][1,7]萘啶

Synthesis Pub Date : 2024-07-15 DOI:10.1055/a-2349-6836
Raj Kamal Sahoo, Gopal Rana, Abhishek Kar, Sourav Ghosh, Umasish Jana
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引用次数: 0

摘要

本研究展示了一种在 FeCl3 催化下利用 1-(2-炔丙基)-2-吡咯醛和芳基胺高效合成二苯并[b,f][1,7]萘啶类化合物的 Povarov 反应,收率极高。本策略的基本特征是:在环境友好型铁催化下,底物制备简单、底物范围广、反应条件温和、原子经济性高且产率高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Iron(III)-Catalysed Povarov Cyclisation for the Synthesis of Fused Dibenzo[b,f][1,7]naphthyridine Embedded Arylpyrrolo Scaffolds

Iron(III)-Catalysed Povarov Cyclisation for the Synthesis of Fused Dibenzo[b,f][1,7]naphthyridine Embedded Arylpyrrolo Scaffolds

An FeCl3-catalyzed Povarov reaction for the efficient synthesis of dibenzo[b,f][1,7]naphthyridines utilizing 1-(2-alkynylaryl)-2-pyrrolecarbaldehydes and arylamines in excellent yields is demonstrated. The essential features of the present strategy are easy preparation of substrates, broad substrate scope, mild reaction conditions, and high atom economy and yields, in the presence of environmentally friendly iron catalysis.

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