Effect of 980 nm Laser Photobiomodulation Using Flat-Top Beam Profile Modifier in Acceleration of Canine Retraction: A Randomized Clinical Trial

Objective : This study aimed to clinically investigate the effectiveness of laser photobiomodulation (laser PBM) using flat-top beam profile modifier in acceleration of canine retraction. The expression of nuclear factor kappa-Β ligand (RANKL) that is involved in alveolar bone remodeling was additionally assessed. Material and Methods: The current split-mouth randomized controlled trial involved twenty patients undergoing extractive orthodontic therapy due to the eruption of ectopic canines. A total of forty canines were assigned to two groups: Group I, which underwent laser irradiation, and Group II, which did not receive irradiation. The canines were evaluated at T0 (pre-retraction), T1 (one month post-retraction), T2 (two months), and T3 (three months) for total retraction displacement. RANKL gingival crevicular fluid samples were collected on days 0, 7, 14, and 30 during laser photobiostimulation sessions. Probing depth was also assessed as a secondary outcome at baseline and three months after the procedure. Results