医生、药剂师和带回家的纳洛酮：有哪些做法？SINFONI 研究

IF 2.2 4区医学 Q3 PHARMACOLOGY & PHARMACY

Therapie Pub Date : 2024-11-01 DOI:10.1016/j.therap.2024.07.001

Mélanie Duval , Aurélie Aquizerate , Emmanuelle Jaulin , Morgane Rousselet , Emmanuelle Kuhn , Alain Guilleminot , Isabelle Nicolleau , Solen Pele , Thomas Herault , Pascal Artarit , Eleni Soulidou-Jacques , Edouard-Jules Laforgue , Caroline Victorri-Vigneau

{"title":"医生、药剂师和带回家的纳洛酮：有哪些做法？SINFONI 研究","authors":"Mélanie Duval , Aurélie Aquizerate , Emmanuelle Jaulin , Morgane Rousselet , Emmanuelle Kuhn , Alain Guilleminot , Isabelle Nicolleau , Solen Pele , Thomas Herault , Pascal Artarit , Eleni Soulidou-Jacques , Edouard-Jules Laforgue , Caroline Victorri-Vigneau","doi":"10.1016/j.therap.2024.07.001","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><div>For several years, both the French Addictovigilance Network and French health authorities have consistently emphasized the need to provide opioid users with take-home naloxone (THN), the specific antidote for opioid overdoses. In March 2022, the French Health Authority recommended systematically assessing the appropriateness of prescribing THN to all opioid users, regardless of the context, and identified 8 high-risk situations. However, at present, THN distribution remains limited, particularly among primary care healthcare professionals. This study, conducted by the Pays de la Loire Centre for Evaluation and Information on Drug Dependence-Addictovigilance and supported by the Regional Health Agency, aims to explore healthcare professionals’ practices and perceptions of these high-risk situations.</div></div><div><h3>Methods</h3><div>An ad-hoc questionnaire was distributed via mail by the project's regional institutional partners to the target healthcare professionals: pharmacists, general practitioners (GPs), physicians practicing in specialities other than general medicine (SPs: algologists, psychiatrists and addictologists). It was completed online from 20/10/2022 to 30/12/2022.</div></div><div><h3>Results</h3><div>Out of the 355 participants (158 pharmacists, 167 GPs and 30 SPs), nearly all were managing patients on opioids. In total, 47.7% of physicians and 27.8% of pharmacists reported experiencing difficulties in dealing with the risk of overdose when prescribing or dispensing opioids to their patients. In the 12months preceding the study, only 8 pharmacists and 34 physicians had prescribed/dispensed THN, primarily due to a lack of awareness of its existence (52% of pharmacists and 72% of physicians) and challenges in addressing the eight overdose risk situations listed by the HAS (ranging from 54% to 83% for all professionals). The best-trained healthcare professionals were those who prescribed the most THN (<em>P</em>   <0.001).</div></div><div><h3>Conclusion</h3><div>The identification of barriers related to THN distribution in the regional SINFONI study, conducted among primary care healthcare professionals managing patients on opioids, highlights the need to develop a training tool specifically tailored for these professionals.</div></div>\",\"PeriodicalId\":23147,\"journal\":{\"name\":\"Therapie\",\"volume\":\"79 6\",\"pages\":\"Pages 623-633\"},\"PeriodicalIF\":2.2000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapie\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S004059572400074X\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapie","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S004059572400074X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}

引用次数: 0

摘要

目标几年来，法国毒瘾警戒网络和法国卫生当局一直强调有必要为阿片类药物使用者提供带回家的纳洛酮（THN），这是治疗阿片类药物过量的特效解毒剂。2022 年 3 月，法国卫生当局建议系统评估向所有阿片类药物使用者开具 THN 处方的适当性，无论其背景如何，并确定了 8 种高风险情况。然而，目前 THN 的分配仍然有限，尤其是在初级保健专业人员中。本研究由卢瓦尔河地区药物依赖性评估与信息中心（Pays de la Loire Centre for Evaluation and Information on Drug Dependence-Addovigance）开展，并得到了地区卫生局的支持，旨在探讨医护专业人员对这些高风险情况的做法和看法。方法该项目地区机构合作伙伴通过邮件向目标医护专业人员（药剂师、全科医生（GPs）、全科医学以外的其他专业医生（SPs：精算师、精神病学家和成瘾学家））分发了一份临时调查问卷。结果在 355 名参与者（158 名药剂师、167 名全科医生和 30 名专科医生）中，几乎所有人都在管理阿片类药物患者。共有 47.7% 的医生和 27.8% 的药剂师表示，在给病人开处方或配药时，在应对过量使用阿片类药物的风险方面遇到了困难。在研究之前的 12 个月中，只有 8 名药剂师和 34 名医生开具/配发过 THN，主要原因是对 THN 的存在缺乏了解（52% 的药剂师和 72% 的医生），以及在应对 HAS 所列的八种用药过量风险情况时遇到困难（所有专业人员的比例从 54% 到 83% 不等）。结论在管理阿片类药物患者的初级医疗保健专业人员中开展的 SINFONI 地区研究发现了与 THN 分配相关的障碍，这突出表明有必要开发一种专门针对这些专业人员的培训工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Physicians, pharmacists and take-home naloxone: What practices? The SINFONI study

Objective

For several years, both the French Addictovigilance Network and French health authorities have consistently emphasized the need to provide opioid users with take-home naloxone (THN), the specific antidote for opioid overdoses. In March 2022, the French Health Authority recommended systematically assessing the appropriateness of prescribing THN to all opioid users, regardless of the context, and identified 8 high-risk situations. However, at present, THN distribution remains limited, particularly among primary care healthcare professionals. This study, conducted by the Pays de la Loire Centre for Evaluation and Information on Drug Dependence-Addictovigilance and supported by the Regional Health Agency, aims to explore healthcare professionals’ practices and perceptions of these high-risk situations.

Methods

An ad-hoc questionnaire was distributed via mail by the project's regional institutional partners to the target healthcare professionals: pharmacists, general practitioners (GPs), physicians practicing in specialities other than general medicine (SPs: algologists, psychiatrists and addictologists). It was completed online from 20/10/2022 to 30/12/2022.

Results

Out of the 355 participants (158 pharmacists, 167 GPs and 30 SPs), nearly all were managing patients on opioids. In total, 47.7% of physicians and 27.8% of pharmacists reported experiencing difficulties in dealing with the risk of overdose when prescribing or dispensing opioids to their patients. In the 12 months preceding the study, only 8 pharmacists and 34 physicians had prescribed/dispensed THN, primarily due to a lack of awareness of its existence (52% of pharmacists and 72% of physicians) and challenges in addressing the eight overdose risk situations listed by the HAS (ranging from 54% to 83% for all professionals). The best-trained healthcare professionals were those who prescribed the most THN (P < 0.001).

Conclusion

The identification of barriers related to THN distribution in the regional SINFONI study, conducted among primary care healthcare professionals managing patients on opioids, highlights the need to develop a training tool specifically tailored for these professionals.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Therapie 医学-药学

CiteScore

3.50

自引率

7.70%

发文量

132

审稿时长

57 days

期刊介绍： Thérapie is a peer-reviewed journal devoted to Clinical Pharmacology, Therapeutics, Pharmacokinetics, Pharmacovigilance, Addictovigilance, Social Pharmacology, Pharmacoepidemiology, Pharmacoeconomics and Evidence-Based-Medicine. Thérapie publishes in French or in English original articles, general reviews, letters to the editor reporting original findings, correspondence relating to articles or letters published in the Journal, short articles, editorials on up-to-date topics, Pharmacovigilance or Addictovigilance reports that follow the French "guidelines" concerning good practice in pharmacovigilance publications. The journal also publishes thematic issues on topical subject. The journal is indexed in the main international data bases and notably in: Biosis Previews/Biological Abstracts, Embase/Excerpta Medica, Medline/Index Medicus, Science Citation Index.