分馏加勒比原生灵芝提取物对三阴性乳腺癌细胞的选择性抗肿瘤潜力

Pharmaceuticals Pub Date : 2024-07-01 DOI:10.3390/ph17070864
Luz V. Arroyo-Cruz, Sebastián Sagardía-González, Kurt Miller, Taotao Ling, Fatima Rivas, Michelle M. Martínez-Montemayor
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摘要

三阴性乳腺癌(TNBC)是一种侵袭性亚型乳腺癌,其特点是没有雌激素受体、孕激素受体和人类表皮生长因子受体 2 型表达。它以高恶性度、侵袭性和转移倾向而著称,由于缺乏有利的治疗靶点,预后较差。从蘑菇中提取的天然产品因其潜在的药用特性而在肿瘤治疗中备受关注。我们的研究小组强调了灵芝对乳腺癌的治疗潜力,建议将其用作辅助治疗。本研究旨在评估在波多黎各发现的两种加勒比原生灵芝物种--Ganoderma multiplicatum(G. multiplicatum)和Ganoderma martinicense(G. martinicense)的潜在抗肿瘤能力。在对这两种灵芝进行培养、收获和分馏后,通过细胞活力测定进行了抗增殖研究。结果表明,大多数馏分对所有细胞株都有一定的细胞毒性,但有 33% 的馏分(F1、F2、F7、F12)对癌细胞模型具有选择性。我们首次证明,原生灵芝物种可以产生具有抗肿瘤细胞特性的代谢物。未来的研究重点将是阐明这些灵芝提取物中最具活性的馏分的结构。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Selective Antineoplastic Potential of Fractionated Caribbean Native Ganoderma Species Extracts on Triple-Negative Breast Cancer Cells
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor type 2 expression. It is known for its high malignancy, invasiveness, and propensity for metastasis, resulting in a poor prognosis due to the absence of beneficial therapeutic targets. Natural products derived from mushrooms have gained significant attention in neoplastic therapy due to their potential medicinal properties. The therapeutic potential of Ganoderma lucidum in breast cancer has been highlighted by our group, suggesting its use as an adjuvant treatment. The present study aims to assess the potential antineoplastic capacity of two Caribbean native Ganoderma species found in Puerto Rico, Ganoderma multiplicatum (G. multiplicatum) and Ganoderma martinicense (G. martinicense). Antiproliferative studies were conducted via cell viability assays after cultivation, harvesting, and fractionation of both species. The obtained results indicate that most of the fractions show some cytotoxicity against all cell lines, but 33% of the fractions (F1, F2, F7, F12) display selectivity towards cancer cell models. We demonstrate for the first time that native Ganoderma species can generate metabolites with anti-TNBC properties. Future avenues will focus on structure elucidation of the most active fractions of these Ganoderma extracts.
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