早产儿甲胎蛋白浓度高度升高

IF 0.2 Q4 PEDIATRICS

Journal of Clinical Neonatology Pub Date : 2024-07-01 DOI:10.4103/jcn.jcn_16_24

Martyna E. Berej, Joanna J. Kośka, Maria Marta Orzeł, Beata Borek-Dzięcioł

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引用次数: 0

摘要

甲胎蛋白（AFP）是一种由肝脏产生的蛋白质。虽然它的生物功能尚未完全清楚，但常被用作癌症的标志物。早产儿的甲胎蛋白水平也很高。早产儿甲胎蛋白水平的参考范围没有明确规定。作者介绍了一例在胎龄 25+5/7 周时出生的男性新生儿。由于在出生后第 24 天的腹部超声波检查中发现肝脏病变以及 AFP 水平显著升高（>430,000 纳克/毫升），这名男婴接受了肿瘤诊断。随着时间的推移，甲胎蛋白水平逐渐下降，在出生后的第 59 天，腹部超声波检查和磁共振成像检查均未发现可疑病灶。根据检查结果，早产及其治疗被认为是导致甲胎蛋白水平偏高的原因。本研究旨在介绍与早产儿甲胎蛋白标准缺失有关的诊断困难。

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Highly Elevated Alpha-fetoprotein Concentration in a Premature Infant

Alpha-1-fetoprotein (AFP) is a protein produced by the liver. Although its biological function is not fully understood, it is often used as a marker for cancer. High levels of AFP are also observed in premature infants. Reference ranges for AFP levels in premature infants are not specified. The authors present a case of a male newborn born at 25+5/7 weeks of gestational age. The boy underwent oncological diagnostics due to the detection, on the 24th day of life, of a liver lesion in an abdominal ultrasound examination, as well as significantly elevated AFP levels (>430,000 ng/mL). With each passing day, the AFP level gradually decreased, and the suspicious lesion was not visualized on abdominal ultrasound or magnetic resonance imaging on the 59th day of life. Based on the conducted examinations, prematurity and its treatment were considered the cause of high AFP levels. The aim of the study was to present the diagnostic difficulties associated with the lack of AFP norms for premature infants.

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来源期刊

Journal of Clinical Neonatology PEDIATRICS-

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期刊介绍： The JCN publishes original articles, clinical reviews and research reports which encompass both basic science and clinical research including randomized trials, observational studies and epidemiology.