The Potential Effect of Bisphosphonate on Teeth Enamel and Dentin Formation in Both Normal and Osteoporotic Albino Rats

Aim: The aim of the current study to establish the effect of Bisphosphonate on Teeth Enamel and Dentin Formation in Both Normal and Osteoporotic Albino Rats. Materials and Methods: This study was included 4 groups of newborn rats, these groups were divided as follow: Group I (negative control), Group II (positive control), Group III (Bisphosphonate group), Group IV (Betamethasone & Bisphosphonate). The numbers of rats in each group were ten rats so the total numbers of rats were forty newborn rats with their average weight 5 grams then according to the date of euthanization of the rats at 10, 20 days; each group was divided into two subgroups. Injection of drugs in the dorsal back of rats were made. The specimens were processed for histological, histomorphometry and statistical analysis. Results: Betamethasone (Group II) made over the developing molar teeth bone resorption but made increasing the thickness of enamel and dentin while Bisphosphonate (group III) made disorientation of odontoblastic layer and decreased the thickness of the mineralized dentin. Dental follicle of the 1st molar appeared discontinuous because it was invaded by bone spicules that reached dental organ at some points at the occlusal portion made deformity of enamel matrix and decreased the thickness of the enamel. In group IV: Both drugs made very thin layer of enamel but made little effect on dentin thickness Conclusion: Betamethasone decreased dentin mineralization but increased its thickness and also decreased the mineralization of ename while Bisphosphonate decreased dentin mineralization and made distortion of odontoblastic layer inside pulp but made more increasing in its thickness.