双膦酸盐对正常和骨质疏松白化大鼠牙釉质和牙本质形成的潜在影响

Somaya M Salawat, Eman Mohammed Hassan
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引用次数: 0

摘要

目的:本研究旨在确定双膦酸盐对正常和骨质疏松白化大鼠牙釉质和牙本质形成的影响。材料和方法:本研究包括 4 组新生大鼠,这些组别划分如下:I 组(阴性对照组)、II 组(阳性对照组)、III 组(双膦酸盐组)、IV 组(倍他米松和双膦酸盐组)。每组 10 只,共 40 只新生大鼠,平均体重 5 克,然后根据大鼠 10 天、20 天的安乐死日期,将每组分为两个亚组。在大鼠背部注射药物。对标本进行组织学、组织形态学和统计学分析。结果倍他米松(II 组)使发育中的磨牙骨吸收,但增加了牙釉质和牙本质的厚度;而双膦酸盐(III 组)使牙本质层失调,并减少了矿化牙本质的厚度。第 1 磨牙的牙泡看起来不连续,因为它被骨刺侵入,骨刺在咬合部分的某些点到达了牙齿器官,导致釉质基质变形,釉质厚度减少。第四组:两种药物都使釉质层变薄,但对牙本质厚度影响不大:倍他米松降低了牙本质的矿化度,但增加了牙本质的厚度,也降低了珐琅质的矿化度,而双膦酸盐降低了牙本质的矿化度,使牙髓内的牙本质层变形,但增加了牙本质的厚度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Potential Effect of Bisphosphonate on Teeth Enamel and Dentin Formation in Both Normal and Osteoporotic Albino Rats
Aim: The aim of the current study to establish the effect of Bisphosphonate on Teeth Enamel and Dentin Formation in Both Normal and Osteoporotic Albino Rats. Materials and Methods: This study was included 4 groups of newborn rats, these groups were divided as follow: Group I (negative control), Group II (positive control), Group III (Bisphosphonate group), Group IV (Betamethasone & Bisphosphonate). The numbers of rats in each group were ten rats so the total numbers of rats were forty newborn rats with their average weight 5 grams then according to the date of euthanization of the rats at 10, 20 days; each group was divided into two subgroups. Injection of drugs in the dorsal back of rats were made. The specimens were processed for histological, histomorphometry and statistical analysis. Results: Betamethasone (Group II) made over the developing molar teeth bone resorption but made increasing the thickness of enamel and dentin while Bisphosphonate (group III) made disorientation of odontoblastic layer and decreased the thickness of the mineralized dentin. Dental follicle of the 1st molar appeared discontinuous because it was invaded by bone spicules that reached dental organ at some points at the occlusal portion made deformity of enamel matrix and decreased the thickness of the enamel. In group IV: Both drugs made very thin layer of enamel but made little effect on dentin thickness Conclusion: Betamethasone decreased dentin mineralization but increased its thickness and also decreased the mineralization of ename while Bisphosphonate decreased dentin mineralization and made distortion of odontoblastic layer inside pulp but made more increasing in its thickness.
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