A Brief Analysis PIK3CA Expression in Head and Neck Squamous Cell Carcinoma

Background: Head and neck squamous cell carcinoma (HNSCC) are the 6th common carcinoma worldwide. PIK3CA gene often dysregulated in many cancers including HNSCC. Here, we aimed to observe PIK3CA expression in HNSCC using publicly free common dataset like TCGA and using bioinformatics tool GEPIA2. Material and methods: Bioinformatics tools often used to predict overall and survival analysis. Here, we used the TCGA dataset to examine PIK3CA expression. We use GEPIA2 to investigate PIK3CA gene expression in HNSCC patients to view overall and disease-free survival. Results: We observedthat the most mutated gene is TP53with 266 (number of cases gene mutated) out of 378 (number of simple somatic mutation) in contrast to PIK3CA gene 63(number of cases gene mutated) out of 378 (number of simple somatic mutation). Overexpression of PIK3CA related to lower risk of death with treatment and lower risk of disease recurrence. Conclusion: To understanding of the role played by the PIK3CA gene to establish a biomarker in head and neck squamous cell carcinoma (HNSCC).