系统性红斑狼疮干眼症

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
E. Candrea, C. Pamfil, Lavinia Prodan, A. Baican, Simona Rednic, Adrian Neacșu, Marta Latasiewicz
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引用次数: 0

摘要

:系统性红斑狼疮是一种病因不明的多器官自身免疫性疾病,以广泛的炎症和严重的发病率和死亡率为特征。器官受累包括关节和皮肤受累、肺部、神经系统和心脏问题、肾脏和血液系统受累以及眼部合并症,既有眼球后部受累,但主要是眼球前部受累。因此,我们旨在评估狼疮患者的干眼症受累情况。我们借助一份基于网络的匿名问卷进行了横断面研究,该问卷同时发放给了红斑狼疮患者和对照组患者。共有 123 名红斑狼疮患者和 200 名对照组答卷者完成了问卷调查。有 25 名红斑狼疮患者(28.9%)被诊断出患有干眼症,而对照组则有 44 人(21.9%)。与 57 名健康答卷者(28.35%)相比,43 名患者(34.60%)出现了干眼症相关症状。经统计分析,狼疮组(P=0.01)、诊断为干眼症的应答者(P=0.01)和使用润滑剂的应答者(P=0.01)报告的干眼症状较多,但干眼症状的发生率与疾病的存在之间没有关联。诊断后狼疮再激活的发作次数与干眼症(P=0.15)和使用润滑性滴泪剂(P 0.01)相关。干眼症状和疾病在红斑狼疮患者中更为常见,应开展进一步研究,以了解这两种疾病实体之间的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dry Eye Disease in Systemic Lupus Erythematosus
: Systemic lupus erythematosus is a multi-organ autoimmune disease of unknown etiology characterized by widespread inflammation and significant morbidity and mortality. Organ affection includes joint and cutaneous involvement, pulmonary, neurological, and cardiac problems, renal and hematological involvement as well as ocular comorbidities, both posterior but mostly anterior ocular involvement. Therefore, we aimed to evaluate dry eye involvement in lupus patients. A cross-sectional study was performed with the aid of a web-based, anonymous questionnaire that was distributed to both patients diagnosed with lupus erythematosus and to a control group. A total number of 123 patients diagnosed with lupus and 200 responders in the control group completed the questionnaire. Dry eye disease has already been diagnosed in 25 lupus patients (28.9%) compared to 44 (21.9%) individuals in the control group. Dry eye-related symptomatology was reported in 43 (34.60%) patients compared to 57 (28.35%) healthy responders. Upon statistical analysis, more symptoms were reported in the lupus group (p=0.01), in responders diagnosed with dry eye syndrome (p 0.01), and in responders using lubrication (p 0.01) but no association was obtained between the incidence of dry eye symptoms and the presence of the disease. The number of episodes of lupus reactivation since diagnosis was correlated with dry eye syndrome (p=0.15) and the use of lubricating tear drops (p 0.01). Dry eye symptoms and disease are more frequent in lupus patients and further research should be performed to understand the connection between these two disease entities.
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来源期刊
Romanian Journal of Military Medicine
Romanian Journal of Military Medicine MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
2
审稿时长
12 weeks
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