肿瘤特征和转移性疾病发生时间对转移性前列腺癌患者肿瘤治疗效果的影响

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS
Mike Wenzel , Malin Lutz , Benedikt Hoeh , Florestan Koll , Cristina Cano Garcia , Carolin Siech , Thomas Steuber , Markus Graefen , Derya Tilki , Luis A. Kluth , Séverine Banek , Felix K.H. Chun , Philipp Mandel
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引用次数: 0

摘要

导言相对于新发转移性前列腺癌(DeNovo metastatic PCa)患者,转移性前列腺癌(mmPCa)患者具有不同的特征和预后。转移性疾病的发生可能会受到原发性 PCa 特征(如格里森评分(GS)或癌症分期)的影响,转移性疾病发生的时间也会影响总生存率(OS)。Kaplan Meier和Cox回归模型根据GS、病理分期和mmPCa发病时间对转移发病时间和OS进行分层测试。结果在341例mmPCa患者中,GS6占8%,GS7和GS8-10占41%,GS7和GS8-10占51%。GS6与GS7与GS8-10的转移性疾病发病时间中位数分别为79个月与54个月与41个月(P = .01)。此外,接受根治性前列腺切除术的 pT1-2 与 pT3-4 mmPCa 患者发生转移的中位时间分别为 64 与 44 个月(P = .027)。在多变量 Cox 回归模型中,较高的 GS 和 pT 分期与较早发生转移有关。此外,在原发性 PCa 诊断与 mmPCa 发病之间的时间间隔为 24 个月与 24-60 个月与 60-120 个月与≥120 个月之间,可以观察到明显的 OS 差异。具体来说,在这些类别中,中位OS分别为56个月与69个月与97个月与未达到(P< .01)。在多变量 Cox 回归中,较短的转移发病时间与较短的 OS 相关。原发性 PCa 诊断与 mmPCa 发病之间的时间间隔越长,患者的 OS 越好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of Tumor Characteristics and Time to Metastatic Disease on Oncological Outcomes in Metachronous Metastatic Prostate Cancer Patients

Introduction

Metachronous metastatic prostate cancer (mmPCa) patients harbor different characteristics and outcomes, relative to DeNovo metastatic PCa patients. Onset of metastatic disease might be influenced by primary PCa characteristics such as Gleason score (GS) or cancer stage, as well as overall survival (OS) by timing of metastatic onset.

Patients and Methods

We relied on an institutional tertiary-care database to identify mmPCa patients. Kaplan Meier and Cox Regression models tested for onset of metastases and OS, stratified according to GS, pathological stage and time to mmPCa.

Results

Of 341 mmPCa patients, 8% harbored GS6 versus 41% versus 51% GS7 and GS8-10. Median time to onset of metastatic disease was 79 versus 54 versus 41 months for GS6 versus GS7 versus GS8-10 (P = .01). Moreover, median time to onset of metastases was 64 versus 44 months for pT1-2 versus pT3-4 mmPCa patients undergoing radical prostatectomy (P = .027). In multivariable Cox regression models, higher GS and pT-stage was associated with earlier onset of metastases. Additionally, significant OS differences could be observed for time interval of < 24 versus 24-60 versus 60-120 versus ≥ 120 months between primary PCa diagnosis and onset of mmPCa. Specifically, median OS was 56 versus 69 versus 97 months versus not reached (P < .01) for these categories. In multivariable Cox regression, shorter time to metastatic onset was associated with shorter OS.

Conclusion

Timing of mmPCa is strongly influenced by grading and pT-stage in real-life setting. OS benefits can be observed with longer time interval between primary PCa diagnosis and onset of mmPCa.

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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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