一项临床研究,旨在监测在印度北部三级医院呼吸内科门诊就诊的各种间质性肺病患者的处方模式、临床疗效和药物不良反应

Q2 Medicine
Sabahat Hasan, Ajay Verma, Shoebul Haque, Farah Asif, Rajendra Nath, Surya Kant, R. K. Dixit
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引用次数: 0

摘要

本研究旨在监测各种间质性肺病(ILD)患者的处方模式、临床结果和药物不良反应(ADR)。 这项前瞻性研究由勒克瑙乔治国王医科大学药理学和治疗学系与呼吸内科学系合作开展,为期 12 个月(2020 年 10 月至 2021 年 9 月)。符合纳入和排除标准的患者共有 77 人。研究人员收集了处方,并在病例报告表中记录了必要的详细信息。研究结束后,在有效问卷--King's Brief ILD(KBILD)问卷的帮助下,对处方模式、临床结果和生活质量进行数据分析。同时,还使用哈特维格严重程度评估量表和纳兰霍因果关系评估量表对ADR(如有)进行了评估。 最常见的 ILD 是急性/慢性超敏性肺炎(HP)。每次就诊的平均用药次数为 4.45 次。心悸是最常见的临床症状。特发性肺纤维化最常见的临床表现是咯血和哮鸣音。研究发现,与基线相比,心理、呼吸困难和活动、胸部症状和总 KBILD 在 3 个月后明显减少,差异有统计学意义(P < 0.01)。23.38%的受试者(18 人)出现了不良反应。报告的最大 ADR 是胃炎(9.09%),其次是肝炎(3.90%)。 在我们的研究中,临床诊断为 HP 的患者比例很高,这突出说明了在对 ILD 患者进行诊断评估时,详细了解环境接触史以避免诊断不准确的重要性。与 ADR 相关的入院治疗是医疗系统中的一个重要问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A clinical study to monitor prescription patterns, clinical outcomes, and adverse drug reactions among patients of various interstitial lung diseases attending respiratory medicine outpatient department at tertiary care hospital in Northern India
The aim of this study was to monitor prescription patterns, clinical outcomes, and adverse drug reactions (ADR) among patients of various interstitial lung diseases (ILDs). This prospective study was conducted in the Department of Pharmacology and Therapeutics in collaboration with the Department of Respiratory Medicine, King George’s Medical University, Lucknow, for a period of 12 months (October 2020–September 2021). A total of 77 patients were enrolled after satisfying the inclusion and exclusion criteria. The prescriptions were collected, and necessary details were noted on the case report form. After completion of the study, the data were analyzed for prescription patterns, clinical outcomes, and quality of life with the help of a validated questionnaire-King’s Brief ILD (KBILD) questionnaire. At the same time, ADRs, if any, were assessed using Hartwig’s Severity Assessment Scale and Naranjo Causality Assessment Scale. The most common ILD was acute/chronic hypersensitivity pneumonitis (HP). Average number of drugs per encounter was 4.45. Crepitations were the most common clinical signs. Clubbing and rhonchi were reported maximum in idiopathic pulmonary fibrosis. It was found that psychological, breathlessness and activities, chest symptoms, and total KBILD reduced significantly after 3 months as compared to baseline with a statistically significant difference as P < 0.01. ADRs were found in 23.38% (18) of the subjects. Maximum ADR reported was gastritis (9.09%), followed by hepatitis (3.90%). The high proportion of patients clinically diagnosed with HP in our study highlights the importance of a detailed environmental exposure history in the diagnostic evaluation of patients with ILD to avoid inaccurate diagnoses. ADR-related hospital admissions are a significant problem in the health-care system.
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来源期刊
Perspectives in Clinical Research
Perspectives in Clinical Research Medicine-Medicine (all)
CiteScore
2.90
自引率
0.00%
发文量
41
审稿时长
36 weeks
期刊介绍: This peer review quarterly journal is positioned to build a learning clinical research community in India. This scientific journal will have a broad coverage of topics across clinical research disciplines including clinical research methodology, research ethics, clinical data management, training, data management, biostatistics, regulatory and will include original articles, reviews, news and views, perspectives, and other interesting sections. PICR will offer all clinical research stakeholders in India – academicians, ethics committees, regulators, and industry professionals -a forum for exchange of ideas, information and opinions.
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