丹参(L.)--生物活性、化学成分和未来展望

Pharmaceuticals Pub Date : 2024-07-01 DOI:10.3390/ph17070859
Stanislava Ivanova, Zoya Dzhakova, Radiana Staynova, K. Ivanov
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引用次数: 0

摘要

自古以来,丹参属(唇形科)植物一直是各国民间医药的重要组成部分。丁香鼠尾草(Salvia verticillata L., S. verticillata)是该属中研究较少的一个品种。然而,它在未来新型植物药的药物发现战略中似乎具有突出的潜力。本综述旨在总结从 S. verticillata 提取物和精油中提取的生物活性和植物化学成分。本综述基于 57 项体外和体内研究的数据。S. verticillata 的化学成分包括不同的协同化合物,如酚酸、类黄酮、萜烯和丹酚酸。虽然在 S. verticillata 提取物中发现了少量丹酚酸 B,但丹酚酸中的主要化合物是丹酚酸 C,这种化合物具有改善肝纤维化、保护心血管和肝脏以及抑制 SARS-CoV-2 感染的潜力。大麻素 2 型受体激动剂 β-石竹烯是 S. verticillata 精油中的主要化合物之一。它是一种在再生医学、神经学、免疫学和其他医学领域具有突出潜力的化合物。关于 S. verticillata 的体内和体外研究都强调了其良好的抗氧化潜力、抗炎、抗菌和抗真菌活性。据报道,由于 S.verticillata 具有抑制乙酰胆碱酯酶的活性,因此也是治疗神经退行性疾病(如阿尔茨海默氏症)的潜在候选药物来源。然而,这方面的研究数量有限。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Salvia verticillata (L.)—Biological Activity, Chemical Profile, and Future Perspectives
Species belonging to the genus Salvia, Lamiaceae, have been deeply involved in the folk medicine of different nations since ancient times. Lilac sage, or Salvia verticillata L. (S. verticillata) is a less studied species from the genus. However, it seems to have a prominent potential for the future drug discovery strategies of novel phytopharmaceuticals. This review aims to summarise the data on the biological activity and the phytochemical profile of extracts and essential oils derived from S. verticillata. This review is based on data from 57 in vitro and in vivo studies. The chemical profile of S. verticillata includes different synergic compounds like phenolic acids, flavonoids, terpenes, and salvianolic acids. Although some small amounts of salvianolic acid B were found in S. verticillata extracts, the major compound among the salvianolic acids is salvianolic acid C, a compound associated with the potential for improving liver fibrosis, cardio- and hepatoprotection, and the inhibition of SARS-CoV-2 infection. The cannabinoid type 2 receptor agonist β-caryophyllene is one of the major compounds in S. verticillata essential oils. It is a compound with a prominent potential in regenerative medicine, neurology, immunology, and other medical fields. The in vivo and the in vitro studies, regarding S. verticillata highlighted good antioxidant potential, anti-inflammatory, antibacterial, and antifungal activity. S.verticillata was also reported as a potential source of drug candidates for the treatment of neurodegenerative diseases such as Alzheimer’s disease, because of the inhibitory activity on the acetylcholinesterase. However, the number of studies in this direction is limited.
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