Dalan Smallwood MD, Richard F. Lockey MD, Narasaiah Kolliputi PhD
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Studies show that <em>Aspergillus</em> is one of the pathogens that is capable of activating PANoptosis via the Z-DNA binding protein 1 (ZBP1) pathway and plays an active role in the inflammation caused by this organism.</p></div><div><h3>Objective</h3><p>This article explores the nature of inflammation in ABPA and ways in which PCD could lead to novel treatment options.</p></div><div><h3>Method</h3><p>PubMed was used to review the literature surrounding <em>Aspergillus</em> infection–related inflammation and PANoptosis.</p></div><div><h3>Results</h3><p>There is evidence that apoptosis and pyroptosis protect against <em>Aspergillus-</em>induced inflammation, whereas necroptosis promotes inflammation.</p></div><div><h3>Conclusion</h3><p>Experimental medications, in particular, necroptosis inhibitors such as necrosulfonamide and necrostatin-1, should be studied for use in the treatment of ABPA.</p></div>","PeriodicalId":75041,"journal":{"name":"The journal of allergy and clinical immunology. 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Treatments center on reducing inflammation with the use of corticosteroids and antifungals. PANoptosis is a new concept in the field of cell death and inflammation that posits the existence of cross talk and a master control system for the 3 programmed cell death (PCD) pathways, namely, apoptosis, pyroptosis, and necroptosis. This concept has revolutionized the understanding of PCD and opened new avenues for its exploration. Studies show that <em>Aspergillus</em> is one of the pathogens that is capable of activating PANoptosis via the Z-DNA binding protein 1 (ZBP1) pathway and plays an active role in the inflammation caused by this organism.</p></div><div><h3>Objective</h3><p>This article explores the nature of inflammation in ABPA and ways in which PCD could lead to novel treatment options.</p></div><div><h3>Method</h3><p>PubMed was used to review the literature surrounding <em>Aspergillus</em> infection–related inflammation and PANoptosis.</p></div><div><h3>Results</h3><p>There is evidence that apoptosis and pyroptosis protect against <em>Aspergillus-</em>induced inflammation, whereas necroptosis promotes inflammation.</p></div><div><h3>Conclusion</h3><p>Experimental medications, in particular, necroptosis inhibitors such as necrosulfonamide and necrostatin-1, should be studied for use in the treatment of ABPA.</p></div>\",\"PeriodicalId\":75041,\"journal\":{\"name\":\"The journal of allergy and clinical immunology. 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引用次数: 0
摘要
背景过敏性支气管肺曲霉菌病(ABPA)是一种罕见的气道疾病,主要影响哮喘和囊性纤维化患者。曲霉菌引起的持续气道炎症会加重潜在的病情,并对呼吸系统造成严重损害。治疗方法主要是使用皮质类固醇和抗真菌药物来减轻炎症。泛凋亡(PANoptosis)是细胞死亡和炎症领域的一个新概念,它认为细胞凋亡、热凋亡和坏死这三种程序性细胞死亡(PCD)途径存在交叉对话和主控制系统。这一概念彻底改变了人们对 PCD 的认识,并为其探索开辟了新的途径。研究表明,曲霉菌是能够通过 Z-DNA 结合蛋白 1(ZBP1)途径激活 PAN 细胞凋亡的病原体之一,并在该病原体引起的炎症中发挥着积极作用。结果有证据表明,细胞凋亡和热凋亡可防止曲霉菌诱发的炎症,而坏死凋亡则会促进炎症。
PANoptosis opens new treatment options for allergic bronchopulmonary aspergillosis
Background
Allergic bronchopulmonary aspergillosis (ABPA) is a rare airway disorder primarily affecting patients with asthma and cystic fibrosis. Persistent airway inflammation brought on by Aspergillus fumigatus exacerbates the underlying condition and can cause significant respiratory damage. Treatments center on reducing inflammation with the use of corticosteroids and antifungals. PANoptosis is a new concept in the field of cell death and inflammation that posits the existence of cross talk and a master control system for the 3 programmed cell death (PCD) pathways, namely, apoptosis, pyroptosis, and necroptosis. This concept has revolutionized the understanding of PCD and opened new avenues for its exploration. Studies show that Aspergillus is one of the pathogens that is capable of activating PANoptosis via the Z-DNA binding protein 1 (ZBP1) pathway and plays an active role in the inflammation caused by this organism.
Objective
This article explores the nature of inflammation in ABPA and ways in which PCD could lead to novel treatment options.
Method
PubMed was used to review the literature surrounding Aspergillus infection–related inflammation and PANoptosis.
Results
There is evidence that apoptosis and pyroptosis protect against Aspergillus-induced inflammation, whereas necroptosis promotes inflammation.
Conclusion
Experimental medications, in particular, necroptosis inhibitors such as necrosulfonamide and necrostatin-1, should be studied for use in the treatment of ABPA.