在拟人模型中使用可变形肝形三维剂量计测量光子放射治疗和质子治疗中运动引起的剂量扰动

IF 3.4 Q2 ONCOLOGY
Simon Vindbæk , Stefanie Ehrbar , Esben Worm , Ludvig Muren , Stephanie Tanadini-Lang , Jørgen Petersen , Peter Balling , Per Poulsen
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引用次数: 0

摘要

背景和目的迄今为止,人们仅通过模拟以及点剂量和平面剂量测量来研究点内运动和变形对临床放射治疗的影响。本研究旨在将拟人三维剂量测量与可变形腹部模型相结合,测量光子放疗中的点内运动和门控的影响,并评估其在质子治疗中的适用性。结果以静止辐照为参考,规划靶体积(PTV)内运动实验的局部 3 %/2 mm 3D 伽玛指数通过率在有门控的情况下高于 97 %(光子)和 78 %(质子),而在无门控的情况下低于 74 %(光子)和 45 %(质子)。结论首次将嵌入可变形腹部模型中的高分辨率可变形拟人三维剂量计用于对表现出呼吸运动的目标进行光子和质子治疗的实验验证。实验表明,门控提高了光子放疗和质子治疗的剂量覆盖率和几何精度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Motion-induced dose perturbations in photon radiotherapy and proton therapy measured by deformable liver-shaped 3D dosimeters in an anthropomorphic phantom

Background and purpose

The impact of intrafractional motion and deformations on clinical radiotherapy delivery has so far only been investigated by simulations as well as point and planar dose measurements. The aim of this study was to combine anthropomorphic 3D dosimetry with a deformable abdominal phantom to measure the influence of intra-fractional motion and gating in photon radiotherapy and evaluate the applicability in proton therapy.

Material and methods

An abdominal phantom was modified to hold a deformable anthropomorphic 3D dosimeter shaped as a human liver. A liver-specific photon radiotherapy and a proton pencil beam scanning therapy plan were delivered to the phantom without motion as well as with 12 mm sinusoidal motion while using either no respiratory gating or respiratory gating.

Results

Using the stationary irradiation as reference the local 3 %/2 mm 3D gamma index pass rate of the motion experiments in the planning target volume (PTV) was above 97 % (photon) and 78 % (proton) with gating whereas it was below 74 % (photon) and 45 % (proton) without gating.

Conclusions

For the first time a high-resolution deformable anthropomorphic 3D dosimeter embedded in a deformable abdominal phantom was applied for experimental validation of both photon and proton treatments of targets exhibiting respiratory motion. It was experimentally shown that gating improves dose coverage and the geometrical accuracy for both photon radiotherapy and proton therapy.

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来源期刊
Physics and Imaging in Radiation Oncology
Physics and Imaging in Radiation Oncology Physics and Astronomy-Radiation
CiteScore
5.30
自引率
18.90%
发文量
93
审稿时长
6 weeks
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