干细胞在口腔种植手术中的应用--当前文献综述

Michelle Im
{"title":"干细胞在口腔种植手术中的应用--当前文献综述","authors":"Michelle Im","doi":"10.46889/jcmr.2024.5205","DOIUrl":null,"url":null,"abstract":"Background: Stem cells have provided promising potential for the field of tissue engineering and regenerative medicine. However, their application in the context of oral surgery and implantology for rehabilitation of bony defects and nerve damage due to iatrogenic injury in the oral cavity remains widely unclear.\n\nAim: The purpose of this study is to review the current role of stem cells and their clinical implications in osseous defect regeneration and nerve repair.\n\nMethods: Human studies based on systematic reviews in English were used to limit bias. Articles were searched on PubMed with key terms: (stem cells) and (oral surgery) and (regeneration).\n\nResults: Bone marrow-derived mesenchymal stem cells injected into sites of horizontal bone deficiencies due to facial injury resulted in the reproduction of alveolar bone in patients undergoing future implant placement. Immunohistological findings from a human clinical trial showed that Periodontal Ligament-Derived Autologous Stem Cells (PDLSCs) demonstrated optimal regenerative capacity of PDL, alveolar bone, cementum and peripheral nerve, as well as improvement of intrabony defects through increased alveolar bone height and decreased depths of bony defects over time. Introduction of umbilical cord-derived stem cells into the oral cavity resulted in successful bone regeneration and reestablishment of lost tissue at sites of injury or pathology. Sensory testing and histomorphometric evaluation concluded that human PDLSCs injected into damaged mental nerves in rats led to enhanced sensory function, sensory neuronal activity and an increase in mRNA expression at the nerve growth receptor level after mental nerve injury.\n\nConclusion: The findings implicate stem cell therapy as a promising alternative to autologous bone grafting and a potential avenue for regeneration of iatrogenic nerve damage. Despite the need for more evidence-based support, their multipotent potential remains a hopeful turning point for multiple applications in oral surgery and implantology.","PeriodicalId":217402,"journal":{"name":"Journal of Clinical Medical Research","volume":"27 42","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Current Understanding of Stem Cells in Oral and Implant Surgery- A Review of the Current Literature\",\"authors\":\"Michelle Im\",\"doi\":\"10.46889/jcmr.2024.5205\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Stem cells have provided promising potential for the field of tissue engineering and regenerative medicine. However, their application in the context of oral surgery and implantology for rehabilitation of bony defects and nerve damage due to iatrogenic injury in the oral cavity remains widely unclear.\\n\\nAim: The purpose of this study is to review the current role of stem cells and their clinical implications in osseous defect regeneration and nerve repair.\\n\\nMethods: Human studies based on systematic reviews in English were used to limit bias. Articles were searched on PubMed with key terms: (stem cells) and (oral surgery) and (regeneration).\\n\\nResults: Bone marrow-derived mesenchymal stem cells injected into sites of horizontal bone deficiencies due to facial injury resulted in the reproduction of alveolar bone in patients undergoing future implant placement. Immunohistological findings from a human clinical trial showed that Periodontal Ligament-Derived Autologous Stem Cells (PDLSCs) demonstrated optimal regenerative capacity of PDL, alveolar bone, cementum and peripheral nerve, as well as improvement of intrabony defects through increased alveolar bone height and decreased depths of bony defects over time. Introduction of umbilical cord-derived stem cells into the oral cavity resulted in successful bone regeneration and reestablishment of lost tissue at sites of injury or pathology. Sensory testing and histomorphometric evaluation concluded that human PDLSCs injected into damaged mental nerves in rats led to enhanced sensory function, sensory neuronal activity and an increase in mRNA expression at the nerve growth receptor level after mental nerve injury.\\n\\nConclusion: The findings implicate stem cell therapy as a promising alternative to autologous bone grafting and a potential avenue for regeneration of iatrogenic nerve damage. Despite the need for more evidence-based support, their multipotent potential remains a hopeful turning point for multiple applications in oral surgery and implantology.\",\"PeriodicalId\":217402,\"journal\":{\"name\":\"Journal of Clinical Medical Research\",\"volume\":\"27 42\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Clinical Medical Research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.46889/jcmr.2024.5205\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Clinical Medical Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.46889/jcmr.2024.5205","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

背景:干细胞在组织工程和再生医学领域具有广阔的应用前景。目的:本研究的目的是回顾干细胞目前在骨缺损再生和神经修复中的作用及其临床意义。方法:为限制偏倚,本研究采用了基于英文系统综述的人类研究。在PubMed上搜索文章,关键词为(干细胞)、(口腔外科)和(再生):结果:将骨髓间充质干细胞注射到因面部损伤导致的水平骨缺损部位,可使将来接受种植手术的患者的牙槽骨得以再生。一项人体临床试验的免疫组织学研究结果表明,牙周韧带衍生自体干细胞(PDLSCs)显示出最佳的牙周韧带、牙槽骨、骨水泥和周围神经再生能力,并随着时间的推移,通过增加牙槽骨高度和减少骨缺损深度来改善骨内缺损。将脐带干细胞引入口腔可成功实现骨再生,并重建损伤或病变部位的损失组织。感官测试和组织形态学评估得出结论,将人类PDLSCs注射到大鼠受损的精神神经中,可增强精神神经损伤后的感觉功能、感觉神经元活性和神经生长受体水平的mRNA表达:结论:研究结果表明,干细胞疗法有望替代自体骨移植,成为先天性神经损伤再生的潜在途径。尽管还需要更多的证据支持,但干细胞的多能潜力仍是口腔外科和种植学多种应用的希望转折点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Current Understanding of Stem Cells in Oral and Implant Surgery- A Review of the Current Literature
Background: Stem cells have provided promising potential for the field of tissue engineering and regenerative medicine. However, their application in the context of oral surgery and implantology for rehabilitation of bony defects and nerve damage due to iatrogenic injury in the oral cavity remains widely unclear. Aim: The purpose of this study is to review the current role of stem cells and their clinical implications in osseous defect regeneration and nerve repair. Methods: Human studies based on systematic reviews in English were used to limit bias. Articles were searched on PubMed with key terms: (stem cells) and (oral surgery) and (regeneration). Results: Bone marrow-derived mesenchymal stem cells injected into sites of horizontal bone deficiencies due to facial injury resulted in the reproduction of alveolar bone in patients undergoing future implant placement. Immunohistological findings from a human clinical trial showed that Periodontal Ligament-Derived Autologous Stem Cells (PDLSCs) demonstrated optimal regenerative capacity of PDL, alveolar bone, cementum and peripheral nerve, as well as improvement of intrabony defects through increased alveolar bone height and decreased depths of bony defects over time. Introduction of umbilical cord-derived stem cells into the oral cavity resulted in successful bone regeneration and reestablishment of lost tissue at sites of injury or pathology. Sensory testing and histomorphometric evaluation concluded that human PDLSCs injected into damaged mental nerves in rats led to enhanced sensory function, sensory neuronal activity and an increase in mRNA expression at the nerve growth receptor level after mental nerve injury. Conclusion: The findings implicate stem cell therapy as a promising alternative to autologous bone grafting and a potential avenue for regeneration of iatrogenic nerve damage. Despite the need for more evidence-based support, their multipotent potential remains a hopeful turning point for multiple applications in oral surgery and implantology.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信