通过一个临床病例看儿童期巴塞杜氏病--一种罕见但复杂的病症

Malad Mohamed, Tadlaoui Abderrahman, Riznat Malak, Jade Issouani, G. Anas
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引用次数: 0

摘要

迄今为止,巴塞杜氏病是儿童甲状腺功能亢进症最常见的病因[1]。在这一特殊人群中,甲状腺机能亢进在生化方面表现明显,临床症状严重[2]。儿童甲状腺功能亢进症还可能导致生长和骨骼成熟加速,最终导致学习成绩下降,因此需要进行良好的筛查和更好的管理。但一旦治疗失败或无法进行治疗,就应考虑进行明确的治疗[3]。对于抗甲状腺药物的使用,我们目前认为DT和BR在生化控制方面没有区别[2,4],这与之前主张在儿童中使用整体置换法的观点不同[5-6]。然而,对于年龄小于 10 岁的 GD 患者来说,全甲状腺切除术是治愈性治疗的首选[3]。我们报告了一个女孩的病例,确诊时她只有两岁半,我们对她进行了一年半的巴塞杜氏病随访。伦理方面的考虑:根据现行法规,本研究报告发表前已获得患儿父母的书面和口头知情同意。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Resistant Graves’ Disease in Childhood, A Rare but Complicated Situation, through a Clinical Case
Graves’ disease is by far the most common cause of hyperthyroidism in children [1]. In this specific population, the hyperthyroidism is willingly biochemically overt and clinically severe [2]. Childhood hyperthyroidism may also cause accelerated growth and bone maturation, and eventually deterioration in academic performance, hence the need for a good screening and a better management. children with GD require prompt treatment, for the most of cases it’s initially medical. But once this fails or is not possible, a definitive treatment should be considered [3]. For the antithyroid drugs use, we currently consider no difference in biochemical control between DT and BR [2,4], unlike previous approaches which argue in favor of the use of bloc-replace method in children [5-6]. However, for a curative treatment, total thyroidectomy is the preferred option for GD patients younger than 10 years [3]. We report the case of a girl who was 2 and a half years old in the moment of diagnose, and whom we followed for Graves' disease for 1 and a half years. Ethical considerations: In accordance with the regulations in force, informed consent, written and verbal, was provided to the parents of the child before the publication of this work.
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