获取多官能化笼状碳氢化合物的最新进展:通向高官能度饱和(生物)苯环异构体之路

Synthesis Pub Date : 2024-07-04 DOI:10.1055/a-2360-8218
S. Nagasawa, Y. Iwabuchi
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引用次数: 0

摘要

最近,人们开发了许多苯环饱和生物异构体,并对其在药物开发中的应用进行了评估。其中大部分是笼状碳氢化合物,它们具有刚性骨架和三维空间。最近合成这些笼状碳氢化合物的努力使人们获得了多功能化的同系物,这些同系物有望成为多功能化苯的(生物)异构体。本综述文章总结了最近报道的获得多官能化(通常超过二取代)笼烃的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Recent Progress in Accessing Multi-functionalized Caged Hydrocarbons: En Route to Highly-Functionalized Saturated (Bio)isosteres of Benzene Ring

Recent Progress in Accessing Multi-functionalized Caged Hydrocarbons: En Route to Highly-Functionalized Saturated (Bio)isosteres of Benzene Ring
Recently, many saturated bioisosteres of benzene ring have been developed, and their application in drug development has been evaluated. Most of these are caged hydrocarbons, which have rigid skeletons and three-dimensional spaces. Recent efforts to synthesize these caged hydrocarbons have enabled access to multi-functionalized congeners that are expected to be (bio)isosteres of multi-functionalized benzenes. This review article summarizes recently reported methods to obtain multi-functionalized (typically more than disubstituted) caged hydrocarbons.
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