特定肠道微生物群(SIM)饮食对代谢性疾病的治疗潜力

Biology Pub Date : 2024-07-04 DOI:10.3390/biology13070498
Nhs Chu, Elaine Chow, Juliana C. N. Chan
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引用次数: 0

摘要

探索膳食益生元与特定肠道微生物组(SIM)之间错综复杂的相互关系,对于解释当前成功的膳食干预措施(包括地中海饮食和高纤维饮食)的机制具有重要意义。这些知识为开发新的天然食物疗法奠定了坚实的基础。可以对 SIM 饮食进行测量和评估,从而为糖尿病、代谢(功能障碍)相关脂肪肝、肥胖症和代谢性心血管疾病等代谢性疾病的治疗奠定可靠的基础。本综述旨在深入研究现有的研究成果,揭示可能的膳食益生元在这一领域的发展前景,并探讨其对临床实践的影响。令人兴奋的是,饮食、微生物群和肠道器官之间的相互作用通过产生短链脂肪酸、胆汁酸和随后的代谢产物而相互促进。这些与代谢相关的微生物包括丁酸球菌、Akkermansia 和 Phascolarctobacterium。通过与肠道微生物群的长期反应,SIM 饮食而不是补充剂有望对健康产生重大影响。最重要的是,文献中一直没有关于不良反应的报道,为这种饮食疗法的安全性提供了坚实的基础。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Therapeutic Potential of the Specific Intestinal Microbiome (SIM) Diet on Metabolic Diseases
Exploring the intricate crosstalk between dietary prebiotics and the specific intestinal microbiome (SIM) is intriguing in explaining the mechanisms of current successful dietary interventions, including the Mediterranean diet and high-fiber diet. This knowledge forms a robust basis for developing a new natural food therapy. The SIM diet can be measured and evaluated to establish a reliable basis for the management of metabolic diseases, such as diabetes, metabolic (dysfunction)-associated fatty liver disease (MAFLD), obesity, and metabolic cardiovascular disease. This review aims to delve into the existing body of research to shed light on the promising developments of possible dietary prebiotics in this field and explore the implications for clinical practice. The exciting part is the crosstalk of diet, microbiota, and gut–organ interactions facilitated by producing short-chain fatty acids, bile acids, and subsequent metabolite production. These metabolic-related microorganisms include Butyricicoccus, Akkermansia, and Phascolarctobacterium. The SIM diet, rather than supplementation, holds the promise of significant health consequences via the prolonged reaction with the gut microbiome. Most importantly, the literature consistently reports no adverse effects, providing a strong foundation for the safety of this dietary therapy.
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