骨髓瘤相关性嗜血细胞淋巴组织细胞增多症--一项全面的病例研究和使用阿纳金雷的新型免化疗方法

EJHaem Pub Date : 2024-07-04 DOI:10.1002/jha2.975
Maged Al-Ammari, Danny Hsu, Adam Bryant
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引用次数: 0

摘要

嗜血细胞淋巴组织细胞增多症(HLH)是一种以过度炎症和组织破坏为特征的免疫反应综合征。嗜血细胞淋巴组织细胞增多症患者同时伴有多发性骨髓瘤(MM)并导致大量死亡的病例为数不多,因此强调了及时诊断的重要性。我们介绍了一例新确诊为多发性骨髓瘤的 78 岁男性患者的病例。随后,他被诊断为 HLH,并接受了阿纳金拉、静脉注射免疫球蛋白和地塞米松的治疗。本病例报告的独特之处在于,它是首例记录在案的使用阿纳金拉治疗骨髓瘤相关 HLH 的病例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Myeloma-associated hemophagocytic lymphohistiocytosis – A comprehensive case study and a novel chemotherapy-free approach with anakinra

Myeloma-associated hemophagocytic lymphohistiocytosis – A comprehensive case study and a novel chemotherapy-free approach with anakinra

Hemophagocytic lymphohistiocytosis (HLH) is an immune response syndrome characterized by excessive inflammation and tissue destruction. A limited number of cases involving HLH patients with concomitant multiple myeloma (MM), leading to significant mortality, have been documented, underscoring the importance of timely diagnosis. We present the case of a 78-year-old previously healthy male admitted to our hospital with a newly diagnosed MM. Subsequently, he was diagnosed with HLH and received treatment with anakinra, intravenous immunoglobulin, and dexamethasone. This case report highlights the unique aspect of being the first documented instance of myeloma-associated HLH treated with anakinra.

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