吸入碱性高渗二价盐可降低难治性慢性咳嗽频率

Hisham Abubakar-Waziri, David A. Edwards, Deen Bhandu Bhatta, James H. Hull, Matthew Rudd, Peter Small, K. Fan Chung
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摘要

慢性咳嗽的治疗仍然是一项挑战。我们对 12 名难治性慢性咳嗽患者进行了一项探索性、单盲、鼻腔生理盐水对照研究,以考察通过鼻腔吸入 pH 值为 8 或 9 的碱性 HDS 成分(SC001)的止咳效果。作为对照组,我们使用相同的手持泵喷雾气雾装置来吸入鼻腔生理盐水。每位受试者在一周的基线、一周的对照治疗和一周的积极治疗期间均使用数字咳嗽监测手表进行连续监测。基线日咳嗽率为 4 至 34 次/小时,基线测试前后的平均视觉模拟评分为 65±17。经对照组调整后,咳嗽次数减少的疗效为 15%(p=0.015)(从第 1 天起)至 23%(p=0.002)(从第 3 天起)。经对照调整后,SC001 pH 值为 9 的疗效最高(5 例),从 25% (p=0.03)(从第 1 天起)到 35% (p=0.02)(从第 3 天起);SC001 pH 值为 8 的疗效最低(7 例),从 9% (p=0.08)(从第 1 天起)到 16% (p=0.02)(从第 3 天起)。在基线监测周(r=0.254,p 值=0.02)和对照监测周(r=0.299,p 值=0.007),每小时咳嗽次数与 VAS 相关。治疗改善了这种相关性(r=0.434,p 值=0.00006)。碱性(pH 值为 9)HDS 气雾剂是一种治疗难治性慢性咳嗽的有效方法,应进一步评估。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inhaled alkaline hypertonic divalent salts reduce refractory chronic cough frequency
Treatment of chronic cough remains a challenge. We hypothesized that inhaled alkaline hypertonic divalent salts (alkaline HDS) might provide relief for refractory chronic cough by laryngeal and tracheal hydration.We conducted an exploratory, single-blinded, nasal-saline-controlled study in 12 refractory chronic cough patients to examine cough-suppression efficacy of an alkaline HDS composition (SC001) at pH 8 or pH 9 administered by nasal inhalation. As control, we used nasal saline with the same hand-held pump spray aerosol device. Each subject was monitored continuously using a digital cough monitor watch for one week of baseline, one week of control treatment, and one week of active treatment.Baseline daily cough rates ranged from 4 to 34 coughs/hour with mean visual analog score 65±17 pre- and post-baseline testing. Control-adjusted efficacy of cough rate reduction ranged from 15% (p=0.015) (from Day 1) to 23% (p=0.002) (from Day 3). Control-adjusted efficacy was highest with SC001 pH 9 (n=5), ranging from 25% (p=0.03) (from Day 1) to 35% (p=0.02) (from Day 3), and lowest for SC001 pH 8 (n=7), ranging from 9% (p=0.08) (from Day 1) to 16% (p=0.02) (from Day 3). Hourly cough counts and VAS correlated for baseline (r=0.254, p-value=0.02) and control (r=0.299, p-value=0.007) monitoring weeks. Treatment improved this correlation (r=0.434, p-value=0.00006). No adverse events were reported.Alkaline (pH 9) HDS aerosol is a promising treatment for refractory chronic cough and should be further evaluated.
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