用疫苗防治疟疾:一个健康框架的启示

Q4 Medicine
H. Sutanto
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引用次数: 0

摘要

疟疾仍然是全球发病率和死亡率的主要原因之一,人们为开发有效疫苗以遏制其影响付出了巨大努力。一体健康 "理念认识到人类、动物和环境健康之间的相互联系,为理解和抗击这一疾病提供了全面的方法。本综述从 "一体健康 "框架的视角审视疟疾疫苗的开发,强调人类、病媒和环境因素在抗击疟疾过程中的融合。我们讨论了疟疾疫苗开发的现状,包括 RTS,S/AS01 疫苗的部署以及 R21/Matrix-M 和 PfSPZ 疫苗等其他候选疫苗的进展。文中探讨了疟原虫复杂的生命周期、遗传多样性以及影响传播的环境因素所带来的挑战。本综述还讨论了可提高疫苗功效和交付的新兴技术和创新。此外,我们还考虑了对成功实施疫苗接种计划至关重要的伦理、社会和经济因素。最后,本综述强调了采用 "统一健康 "方法开发疟疾疫苗的重要性,提倡采取综合措施应对疟疾控制和根除的多方面挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Combating Malaria with Vaccines: Insights from the One Health Framework
Malaria remains a leading cause of morbidity and mortality worldwide, with significant efforts directed towards developing effective vaccines to curb its impact. The One Health concept, recognizing the interconnectedness of human, animal, and environmental health, offers a comprehensive approach to understanding and combating this disease. This review examines the development of malaria vaccine through the lens of the One Health framework, highlighting the integration of human, vector, and environmental factors in the fight against malaria. We discuss the current landscape of malaria vaccine development, including the deployment of the RTS,S/AS01 vaccine and the progress of other candidates such as the R21/Matrix-M and PfSPZ vaccine. The challenges posed by the complex lifecycle of the malaria parasite, its genetic diversity, and the environmental factors influencing transmission are explored. This review also discusses emerging technologies and innovations that could enhance vaccine efficacy and delivery. Additionally, we consider ethical, social, and economic factors critical to the successful implementation of vaccination programs. In concluding, this review underscores the importance of adopting a One Health approach to malaria vaccine development, advocating for integrated efforts to address the multifaceted challenges of malaria control and eradication.
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来源期刊
Acta Microbiologica Hellenica
Acta Microbiologica Hellenica Medicine-Microbiology (medical)
CiteScore
0.20
自引率
0.00%
发文量
6
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