一名 11 岁甲状腺自身免疫功能失调患者的新发癫痫状态：小儿桥本脑病病例报告

IF 0.2 Q4 PEDIATRICS

Journal of Pediatric Epilepsy Pub Date : 2024-07-08 DOI:10.1055/s-0044-1788053

Aldo F. Costa, J. Fernández-Ramos, Cristina Cazorla, Eduardo López-Laso

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引用次数: 0

摘要

桥本脑病（HE）是一种与甲状腺抗体（Ab）阳性有关的神经精神综合征。其病理生理学仍存在争议，儿童病例被认为是罕见的。我们介绍了一例患有新发难治性癫痫状态（NORSE）的11岁女孩的病例，她最初对皮质类固醇反应良好，但随后需要接受霉酚酸酯的二线治疗。对于出现疑似自身免疫性 NORSE 的儿童，如果没有发现自身免疫性脑炎传统抗体，则必须考虑 HE。

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New-Onset Status Epilepticus in an 11-year-old Patient with Thyroid Autoimmune Dysfunction: A Case Report of Pediatric Hashimoto Encephalopathy

Hashimoto encephalopathy (HE) is a neuropsychiatric syndrome associated with positive thyroid antibodies (Ab). Its pathophysiology is still in debate and pediatric cases are considered rare. We present a case of an 11-year-old girl with new-onset refractory status epilepticus (NORSE) who presented a good initial response to corticosteroids but then required a second line of treatment with mycophenolate. In children presenting with NORSE of suspected autoimmune origin and no identification of autoimmune encephalitis traditional Ab, HE must be considered.

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Journal of Pediatric Epilepsy PEDIATRICS-

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期刊介绍： The Journal of Pediatric Epilepsy is an English multidisciplinary peer-reviewed international journal publishing articles on all topics related to epilepsy and seizure disorders, epilepsy surgery, neurology, neurosurgery, and neuropsychology in childhood. These topics include the basic sciences related to the condition itself, the differential diagnosis, natural history, and epidemiology of seizures, and the investigation and practical management of epilepsy (including drug treatment, neurosurgery and non-medical and behavioral treatments). Use of model organisms and in vitro techniques relevant to epilepsy are also acceptable. Journal of Pediatric Epilepsy provides an in-depth update on new subjects and current comprehensive coverage of the latest techniques used in the diagnosis and treatment of childhood epilepsy.