漂浮给药系统概述

Mr. Prachet Bagewadikar, Dr. B. D. Tiwari, Utkarsha Mhetre, Diksha Kulkarni, Aaishwarya Kulkarni
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摘要

浮动给药系统(FDDS)的目标是将当前的重点放在基本浮动机制上,以达到胃保留时间。本书深入探讨了浮动给药系统的最新进展,包括影响胃保留时间的配方和生理因素、浮动系统的设计方法及其分类和配方特点。由于剂型在胃中停留的时间比传统剂型长,因此延长和控制胃排空时间的能力是一项重要资产。剂型的胃排空是一个变化很大的过程。具有胃保留系统的药物在胃中的停留时间更长,从而提高了生物利用度,减少了药物浪费,并提高了在高 pH 值环境中溶解度较低的药物的溶解度。这些优点可在数小时内实现。本综述简要介绍了漂浮给药装置
本文章由计算机程序翻译,如有差异,请以英文原文为准。
An Overview of Floating Drug Delivery System
The goal of Floating Drug Delivery Systems (FDDS) is to arrange the current emphasis on the basic flotation mechanism to attain stomach retention time. The most current advancements in FDDS are thoroughly discussed, including the formulation and physiological factors influencing stomach retention, methods for designing floating systems, and the characteristics of their classification and formulation. Since dosage forms stay in the stomach longer than conventional dosage forms, the capacity to extend and control the gastric emptying time is a major asset. Gastric emptying of dosage forms is a highly variable process. Drugs with gastroretentive systems have a much longer residence time in the stomach area, improving bioavailability, decreasing drug waste, and increasing solubility for medications that are less soluble in high pH environments. These benefits are achieved over a period of many hours. This review provides a brief overview of floating medication delivery devices
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