肿瘤学中的吲哚化合物:治疗潜力和机制见解

Pharmaceuticals Pub Date : 2024-07-10 DOI:10.3390/ph17070922
Sara M. Hassan, A. Farid, Siva S Panda, M. Bekheit, Holden Dinkins, W. Fayad, A. S. Girgis
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引用次数: 0

摘要

癌症仍然是一个严峻的全球健康挑战,目前的治疗方式,如化疗、放疗、手术和靶向治疗,往往因疗效低和副作用大而受到阻碍。吲哚支架是一种重要的杂环结构,已成为抗癌领域前景广阔的候选药物。本综述综述了过去五年来在开发天然和合成吲哚类似物方面取得的最新进展,重点介绍了它们对各种癌症类型的抗增殖活性。这些类似物根据其对常见癌症类型的疗效进行了分类,并通过生化实验证明了它们的抗增殖特性。本综述的重点是阐明这些化合物的作用机制。鉴于传统癌症疗法的局限性,开发选择性更强、副作用更小的靶向治疗药物仍然是肿瘤研究的重点。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Indole Compounds in Oncology: Therapeutic Potential and Mechanistic Insights
Cancer remains a formidable global health challenge, with current treatment modalities such as chemotherapy, radiotherapy, surgery, and targeted therapy often hindered by low efficacy and adverse side effects. The indole scaffold, a prominent heterocyclic structure, has emerged as a promising candidate in the fight against cancer. This review consolidates recent advancements in developing natural and synthetic indolyl analogs, highlighting their antiproliferative activities against various cancer types over the past five years. These analogs are categorized based on their efficacy against common cancer types, supported by biochemical assays demonstrating their antiproliferative properties. In this review, emphasis is placed on elucidating the mechanisms of action of these compounds. Given the limitations of conventional cancer therapies, developing targeted therapeutics with enhanced selectivity and reduced side effects remains a critical focus in oncological research.
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