与年龄相关的口腔疾病中的混合唾液化学参数变化

M. Kopenkin, L. Polushina, E. A. Sementsova, Y. Mandra, V. Bazarnyi
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引用次数: 0

摘要

导言。口腔老年性疾病,如慢性牙周炎(CP)和口腔扁平苔藓(OLP)的发病率在老年人和高龄老人中有所增加。本研究旨在评估与年龄相关的口腔疾病中混合唾液生化指标的变化,并评估通过总蛋白浓度进行校正的影响。研究对象包括 86 名 60 至 74 岁的老年人。他们被分为以下几组:牙齿过度磨损患者(16 人);中度 CP 患者(22 人);OLP 患者(28 人);健康人(20 人)。使用试剂条 Siemens Multistix 10 SG(美国)、分析仪 Siemens Clinitek Status+(美国)、化学分析仪 Mindray BS-240Pro(中国)。共测定了 16 种生化指标和 4 种计算指数。唾液结果未经任何校正,按总蛋白浓度进行校正。结果发现,OLP 患者的比重高于对照组,总蛋白和钙的含量也高于对照组。与健康人相比,CP 患者的 c 反应蛋白水平更高。经校正后,组间无差异。这些数据与描述与年龄有关的口腔疾病的混合唾液变化的文献资料相符。结论:混合唾液化学标记物在老年口腔疾病中发生了变化。结论:与年龄相关的口腔疾病会导致混合唾液化学标记发生变化。有必要找到最佳的校正方法,因为稀释和粘度会对混合唾液的研究结果产生重大影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mixed Saliva Chemical Parameters Changes in Age‑Related Oral Diseases
Introduction. The prevalence of oral cavity age-related diseases, such as chronic periodontitis (CP) and oral lichen planus (OLP) increases in the elderly and senile age people. The aim of the study was to evaluate changes in the biochemical parameters of mixed saliva in age-related oral diseases and evaluate impact of correction by total protein concentration.Materials and methods. The study included 86 elderly people from 60 to 74 years. They were divided into following groups: excessive attrition of teeth patients (n = 16); moderate CP patients (n = 22); OLP patients (n = 28); healthy peoples (n = 20). Reagent strips Siemens Multistix 10 SG (USA), analyzer Siemens Clinitek Status+ (USA), chemistry analyzer Mindray BS-240Pro (China) were used. In total, 16 biochemical markers and 4 calculated indices were determined. Saliva results were expressed without any correction, and corrected by total protein concentration.Results. It was found that OLP patients differed by a higher specific gravity and an increased level of total protein and calcium from the control group. CP patients had a higher level of c-reactive protein in compared to the healthy peoples. There were no differences between groups after correction.Discussion. The data corresponded to literature sources describing mixed saliva changes in age-related oral diseases. However, correction methods practically were not used in the considered works.Conclusion. Mixed saliva chemical markers changed in age-related oral diseases. It is necessary to find the optimal correction method because dilution and viscosity can significantly affect mixed saliva research results.
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