猴子(不包括作为代谢综合征研究模型的猿类

S. Orlov, Y. Uspensky, Yu. A. Fominykh, Yu. A. Kolesnik, A. V. Panchenko
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引用次数: 0

摘要

目的用以下关键词在 PubMed 和 Scopus 数据库中检索全文:非人灵长类、猴子、肥胖、糖尿病、代谢综合征、胰岛素、动脉粥样硬化、高血压。所选文章描述了涉及以下猴子物种的研究:眼镜猴(Macaca fascicularis)、猕猴(Macaca mulatta)、狒狒(Papio sp.)、叼猴(Cercopithecus aethiops)和普通狨猴(Callithrix jacchus)。在所有被审查的猴子物种中,各种代谢综合征的标准都得到了证实。研究发现,猕猴与人类有许多相似之处:患有肥胖症、胰岛素抵抗和 2 型糖尿病的猕猴表现出总胆固醇、甘油三酯和游离脂肪酸增加,高密度脂蛋白胆固醇浓度降低。肥胖和胰岛素抵抗是碳水化合物代谢受损的前兆。血压随着胰岛素抵抗的发展而升高。人类和猴子在遗传和环境风险因素方面的相似性对代谢综合征的发展非常重要。所审查的数据表明,在生物医学研究中使用猴子仍然是研究发病机制和评估针对临床上重要的代谢疾病(包括肥胖、血脂异常、动脉粥样硬化、2 型糖尿病以及可能与代谢综合征相关的其他疾病)的新治疗策略的有效性和安全性的不可或缺的资源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Monkeys excluding apes as a model for studies on metabolic syndrome
Aim. To summarize the results of research on metabolic syndrome in monkeys excluding apes and to conduct a comparison with humans.A search for full-text publications in PubMed and Scopus databases was carried out using the following keywords: nonhuman primate, monkey, obesity, diabetes mellitus, metabolic syndrome, insulin, atherosclerosis, hypertension. Articles were selected that describe studies involving the following monkey species: cynomolgus monkeys (Macaca fascicularis), rhesus macaques (Macaca mulatta), baboons (Papio sp.), grivets (Cercopithecus aethiops), and common marmosets (Callithrix jacchus). The development of various metabolic syndrome criteria was demonstrated in all monkey species reviewed. Many similarities with humans were revealed: macaques with obesity, insulin resistance, and type 2 diabetes mellitus demonstrated an increase in total cholesterol, triglycerides, and free fatty acids and a decrease in the concentration of high-density lipoprotein cholesterol. Obesity and insulin resistance were precursors to impaired carbohydrate metabolism. Blood pressure increased along with the progression of insulin resistance. The similarity of genetic and environmental risk factors between humans and monkeys is important in the development of metabolic syndrome. The reviewed data suggest that the use of monkeys in biomedical research remains an indispensable resource for the study of pathogenesis and assessment of the efficacy and safety of new therapeutic strategies targeting clinically important metabolic diseases, including obesity, dyslipidemia, atherosclerosis, type 2 diabetes mellitus, and, possibly, other conditions associated with metabolic syndrome.
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