浸润性导管癌转移至膀胱的乳腺癌病例报告

Tian Hou, Guangtai Shen, Xin Hu, Tubuxin Bai, Heping He, Zhipeng Zhang, Wenqi Bao, Ruibo Tian, Xiao-jie Yu, Tianyang Sun, Xiaoli Ding, Xin Wang, Yuhai Zhang
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摘要

乳腺癌是全球妇女最常见的恶性肿瘤,主要表现为浸润性导管癌(IDC),通常会转移到骨骼、肺部和肝脏。然而,转移到膀胱的情况极为罕见,记录在案的病例很少,现有文献对其了解也很有限。 一位 57 岁的女性患者曾患 IDC,左侧乳房出现肿块,最初接受了化疗和改良根治性乳房切除术。几年后,她出现泌尿系统症状,经检查发现多发性膀胱肿瘤和右肾积水。包括超声波和 CT 扫描在内的诊断成像证实了这些发现。 IDC 膀胱转移的发现凸显了非典型表现给诊断带来的巨大挑战。该病例强调了考虑已知乳腺癌患者异常转移部位的重要性,尤其是当患者出现非特异性泌尿系统症状时。本报告探讨了这种罕见转移发生的潜在病理生理机制,并讨论了对临床实践的影响。 本病例说明,对于有异常症状和乳腺癌病史的患者,我们亟需提高警惕并进行全面评估。它呼吁采用更全面的诊断方法和可能调整的治疗方案来更好地处理非典型转移,最终目的是改善患者的预后,加深对转移性乳腺癌行为的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case report of breast cancer metastasis to the bladder from invasive ductal carcinoma
Breast cancer is the most common malignancy among women worldwide, predominantly manifesting as invasive ductal carcinoma (IDC), which usually metastasizes to the bones, lungs, and liver. However, metastasis to the bladder is exceedingly rare, with few documented cases and limited understanding in the existing literature. A 57-year-old woman with a history of IDC presented with a lump in her left breast and was initially treated with chemotherapy and a modified radical mastectomy. Years later, she developed urinary symptoms, which upon investigation revealed multiple bladder tumors and right kidney hydronephrosis. Diagnostic imaging, including ultrasound and CT scans, supported these findings. The discovery of bladder metastasis from IDC highlights significant diagnostic challenges due to the atypical presentation. The case underscores the importance of considering unusual metastatic sites in patients with known breast cancer, especially when they present with non-specific urinary symptoms. This report explores the potential pathophysiological mechanisms of such rare metastatic occurrences and discusses the implications for clinical practice. This case exemplifies the critical need for heightened awareness and thorough evaluation in patients with unusual symptoms and a history of breast cancer. It calls for more comprehensive diagnostic approaches and possibly adjusted treatment protocols to better manage atypical metastases, ultimately aiming to improve patient outcomes and contribute to a deeper understanding of metastatic breast cancer behavior.
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