{"title":"福米霉素生物合成的化学过程","authors":"Nigel G. J. Richards, James H. Naismith","doi":"10.3389/fchbi.2024.1428646","DOIUrl":null,"url":null,"abstract":"Remarkable progress has been made to elucidate the structural and mechanistic enzymology of the biosynthetic pathways that give rise to naturally occurring C-nucleosides. These compounds are generally cytotoxic and exhibit interesting antiviral, antibiotic and anti-parasitic activity. Here we review current knowledge concerning formycin biosynthesis and highlight deficiencies in our understanding of key chemical transformations in the pathway.","PeriodicalId":123291,"journal":{"name":"Frontiers in Chemical Biology","volume":"52 19","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The chemistry of Formycin biosynthesis\",\"authors\":\"Nigel G. J. Richards, James H. Naismith\",\"doi\":\"10.3389/fchbi.2024.1428646\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Remarkable progress has been made to elucidate the structural and mechanistic enzymology of the biosynthetic pathways that give rise to naturally occurring C-nucleosides. These compounds are generally cytotoxic and exhibit interesting antiviral, antibiotic and anti-parasitic activity. Here we review current knowledge concerning formycin biosynthesis and highlight deficiencies in our understanding of key chemical transformations in the pathway.\",\"PeriodicalId\":123291,\"journal\":{\"name\":\"Frontiers in Chemical Biology\",\"volume\":\"52 19\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-12\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Chemical Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/fchbi.2024.1428646\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Chemical Biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fchbi.2024.1428646","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在阐明产生天然 C 核苷的生物合成途径的结构和机理酶学方面取得了显著进展。这些化合物通常具有细胞毒性，并表现出有趣的抗病毒、抗生素和抗寄生虫活性。在此，我们回顾了目前有关甲氨霉素生物合成的知识，并强调了我们对该途径中关键化学转化的认识存在的不足。
Remarkable progress has been made to elucidate the structural and mechanistic enzymology of the biosynthetic pathways that give rise to naturally occurring C-nucleosides. These compounds are generally cytotoxic and exhibit interesting antiviral, antibiotic and anti-parasitic activity. Here we review current knowledge concerning formycin biosynthesis and highlight deficiencies in our understanding of key chemical transformations in the pathway.
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