毒理学评价验证了大鼠口服蒸熟蚕粉的安全性

Foods Pub Date : 2024-07-13 DOI:10.3390/foods13142209
Young-Min Han, Da-Young Lee, Moon-Young Song, Eun-Hee Kim
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引用次数: 0

摘要

在全球范围内,食用昆虫产业因其对粮食安全和环境可持续性的潜在贡献而正在兴起。食用昆虫正迅速融入替代食品和新药品的开发中。蚕以蛋白质含量高而著称,不仅是人类食品和动物饲料的潜在新来源,而且在传统上还被用于药用目的。然而,传统的蚕难以摄取。为了解决这个问题,我们开发了一种蒸熟并冷冻干燥的成熟蚕幼虫粉(SMSP),为了进一步研究和应用,有必要对其潜在的毒性和食品安全性进行调查。因此,本研究旨在评估熟蚕幼虫粉的毒性。本研究根据经合组织准则对蚕蛹粉进行了毒性评估。对雄性和雌性 SD 大鼠进行了口服重复给药研究,剂量分别为 625、1250 和 2500 毫克/千克/天,持续 4 周和 13 周。在临床症状、体重、水和食物摄入量、尿液检测、血液学、临床生物化学、大体检查结果或组织病理学检查方面,均未观察到毒理学变化。总之,SMSP 的无观测不良效应水平(NOAEL)为 2500 毫克/千克/天,在大鼠的任何性别中均未发现目标器官。这些结果表明,SMSP 是安全的,没有副作用,有潜力用作食用配料和保健功能食品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toxicological Evaluation Verifies the Safety of Oral Administration of Steamed Mature Silkworm Powder in Rats
Globally, the edible insect industry is emerging due to its potential contributions to food security and environmental sustainability. Edible insects are rapidly being integrated into the development of alternative foods and new pharmaceuticals. Silkworms, known for their high protein content, are not only a potential new source of human food and animal feed but have also been traditionally used for medicinal purposes. However, conventional silkworms are difficult to ingest. To address this, we have developed a steamed and freeze-dried mature silkworm larva powder (SMSP), and it is essential to investigate its potential toxicity and food safety for further studies and applications. Therefore, this study aimed to evaluate the toxicity of SMSP. A toxicity assessment of SMSP was conducted according to OECD guidelines. An oral repeat-administration study was performed on male and female SD rats at doses of 625, 1250, and 2500 mg/kg/day for 4 and 13 weeks. No toxicological changes were observed in clinical signs, body weight, water and food intake, urine tests, hematology, clinical biochemistry, gross findings, or histopathological examination. In conclusion, the no observed adverse effect level (NOAEL) of SMSP was 2500 mg/kg/day, with no target organs identified in either sex of the rats. These results suggest that SMSP is safe, is without side effects and has potential for use as an edible ingredient and in health functional food applications.
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