新型胶原膜制剂与伊立替康或米诺环素在脑癌中的潜在应用

Materials Pub Date : 2024-07-15 DOI:10.3390/ma17143510
Andreea-Anamaria Idu, M. A. Albu Kaya, Ileana Rău, N. Radu, C. Dinu-Pîrvu, M. Ghica
{"title":"新型胶原膜制剂与伊立替康或米诺环素在脑癌中的潜在应用","authors":"Andreea-Anamaria Idu, M. A. Albu Kaya, Ileana Rău, N. Radu, C. Dinu-Pîrvu, M. Ghica","doi":"10.3390/ma17143510","DOIUrl":null,"url":null,"abstract":"Our study explores the development of collagen membranes with integrated minocycline or irinotecan, targeting applications in tissue engineering and drug delivery systems. Type I collagen, extracted from bovine skin using advanced fibril-forming technology, was crosslinked with glutaraldehyde to create membranes. These membranes incorporated minocycline, an antibiotic, or irinotecan, a chemotherapeutic agent, in various concentrations. The membranes, varying in drug concentration, were studied by water absorption and enzymatic degradation tests, demonstrating a degree of permeability. We emphasize the advantages of local drug delivery for treating high-grade gliomas, highlighting the targeted approach’s efficacy in reducing systemic adverse effects and enhancing drug bioavailability at the tumor site. The utilization of collagen membranes is proposed as a viable method for local drug delivery. Irinotecan’s mechanism, a topoisomerase I inhibitor, and minocycline’s broad antibacterial spectrum and inhibition of glial cell-induced membrane degradation are discussed. We critically examine the challenges posed by the systemic administration of chemotherapeutic agents, mainly due to the blood–brain barrier’s restrictive nature, advocating for local delivery methods as a more effective alternative for glioblastoma treatment. These local delivery strategies, including collagen membranes, are posited as significant advancements in enhancing therapeutic outcomes for glioblastoma patients.","PeriodicalId":503043,"journal":{"name":"Materials","volume":"15 25","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Novel Collagen Membrane Formulations with Irinotecan or Minocycline for Potential Application in Brain Cancer\",\"authors\":\"Andreea-Anamaria Idu, M. A. Albu Kaya, Ileana Rău, N. Radu, C. Dinu-Pîrvu, M. Ghica\",\"doi\":\"10.3390/ma17143510\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Our study explores the development of collagen membranes with integrated minocycline or irinotecan, targeting applications in tissue engineering and drug delivery systems. Type I collagen, extracted from bovine skin using advanced fibril-forming technology, was crosslinked with glutaraldehyde to create membranes. These membranes incorporated minocycline, an antibiotic, or irinotecan, a chemotherapeutic agent, in various concentrations. The membranes, varying in drug concentration, were studied by water absorption and enzymatic degradation tests, demonstrating a degree of permeability. We emphasize the advantages of local drug delivery for treating high-grade gliomas, highlighting the targeted approach’s efficacy in reducing systemic adverse effects and enhancing drug bioavailability at the tumor site. The utilization of collagen membranes is proposed as a viable method for local drug delivery. Irinotecan’s mechanism, a topoisomerase I inhibitor, and minocycline’s broad antibacterial spectrum and inhibition of glial cell-induced membrane degradation are discussed. We critically examine the challenges posed by the systemic administration of chemotherapeutic agents, mainly due to the blood–brain barrier’s restrictive nature, advocating for local delivery methods as a more effective alternative for glioblastoma treatment. These local delivery strategies, including collagen membranes, are posited as significant advancements in enhancing therapeutic outcomes for glioblastoma patients.\",\"PeriodicalId\":503043,\"journal\":{\"name\":\"Materials\",\"volume\":\"15 25\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3390/ma17143510\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ma17143510","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

我们的研究探索了集成米诺环素或伊立替康的胶原蛋白膜的开发,目标是应用于组织工程和药物输送系统。采用先进的纤维形成技术从牛皮中提取的 I 型胶原蛋白与戊二醛交联后形成了膜。这些膜含有不同浓度的抗生素米诺环素或化疗药物伊立替康。通过吸水和酶降解试验对不同药物浓度的膜进行了研究,结果表明膜具有一定的渗透性。我们强调了局部给药治疗高级别胶质瘤的优势,突出了靶向方法在减少全身不良反应和提高肿瘤部位药物生物利用度方面的功效。利用胶原蛋白膜进行局部给药是一种可行的方法。我们讨论了伊立替康作为拓扑异构酶 I 抑制剂的作用机制,以及米诺环素广泛的抗菌谱和对胶质细胞诱导的膜降解的抑制作用。我们批判性地审视了全身给药化疗药物所带来的挑战,这主要是由于血脑屏障的限制性,我们主张采用局部给药方法作为治疗胶质母细胞瘤的更有效替代方案。包括胶原蛋白膜在内的这些局部给药策略被认为是提高胶质母细胞瘤患者治疗效果的重大进步。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Novel Collagen Membrane Formulations with Irinotecan or Minocycline for Potential Application in Brain Cancer
Our study explores the development of collagen membranes with integrated minocycline or irinotecan, targeting applications in tissue engineering and drug delivery systems. Type I collagen, extracted from bovine skin using advanced fibril-forming technology, was crosslinked with glutaraldehyde to create membranes. These membranes incorporated minocycline, an antibiotic, or irinotecan, a chemotherapeutic agent, in various concentrations. The membranes, varying in drug concentration, were studied by water absorption and enzymatic degradation tests, demonstrating a degree of permeability. We emphasize the advantages of local drug delivery for treating high-grade gliomas, highlighting the targeted approach’s efficacy in reducing systemic adverse effects and enhancing drug bioavailability at the tumor site. The utilization of collagen membranes is proposed as a viable method for local drug delivery. Irinotecan’s mechanism, a topoisomerase I inhibitor, and minocycline’s broad antibacterial spectrum and inhibition of glial cell-induced membrane degradation are discussed. We critically examine the challenges posed by the systemic administration of chemotherapeutic agents, mainly due to the blood–brain barrier’s restrictive nature, advocating for local delivery methods as a more effective alternative for glioblastoma treatment. These local delivery strategies, including collagen membranes, are posited as significant advancements in enhancing therapeutic outcomes for glioblastoma patients.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信