尿路微生物群和尿液蛋白质组在尿路结石发病机制中的作用

N. A. Verlov, V. Burdakov, L. A. Ivanova, I. A. Kulakov, A. A. Bogdanov, V. Emanuel
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引用次数: 0

摘要

尽管药物治疗和碎石技术已经取得了一定的成就,但由于发病率的增加,特别是反复发作的病程,尿路结石的病因学研究是一个具有普遍意义的社会健康问题。病理结晶一方面被认为是尿液中一些矿物质成分的溶解度超过阈值的结果,另一方面被认为是排尿的主要蛋白质组--尿调素(UMOD)翻译后缺陷的结果,尿调素在健康人体内展示了一个确保生物物理平衡稳定的卫生遗传系统:尿液的胶体特性。此外,尽管尿路感染是导致尿路结石的一个已知因素,但 UMOD 通过结合传染性病原体的甘露糖丸,阻止了细菌与尿路细胞的接触。通过对健康人的尿液与大肠杆菌共同作用进行建模,证明尿液中聚合尿泌素浓度的降低是增加草酸钙结晶形成风险的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Role of urinary tract microbiota and urine proteome in urolithiasis pathogenesis
The pathogenetic approach to the metaphylaxis of urolithiasis is universally a socially significant health problem due to the increase in morbidity and, especially, its recurrent course, despite the achievements of pharmacotherapy and the use of lithotripsy. Pathological crystallogenesis is considered as a consequence of exceeding the solubility threshold of a number of mineral components of urine, on the one hand, and as a consequence of posttranslational defects of the main proteome of urination - uromodulin (UMOD), demonstrating in healthy people a sanogenetic system for ensuring the stability of biophysical homeostasis: colloidal properties of urine. However, in addition, UMOD, by binding mannose-dependent pills of infectious agents, blocks the contact of bacteria with urotheliocytes, despite the fact that infection of the urinary tract is a known factor of urolithiasis. By modeling the urine of healthy individuals by coincubation with E. coli bacteria, a decrease in the concentration of polymerized uromodulin in urine was demonstrated as a factor in increasing the risk of formation of calcium oxalate crystals
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