严重 COVID-19 感染后脑肌酸和 N-乙酰天冬氨酸浓度降低:磁共振波谱研究

Jelena Ostojic, D. Kozic, Sergej M. Ostojic, Aleksandra DJ Ilic, Vladimir Galic, J. Matijašević, Dusan Dragicevic, Otto Barak, J. Boban
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引用次数: 0

摘要

背景/目的:本研究旨在利用磁共振光谱(MRS)评估冠状病毒病(COVID-19)康复后的脑代谢情况,并测试疾病严重程度对脑代谢物的影响。研究方法我们对 81 名磁共振成像结果正常且已从 COVID-19 康复的患者(男性 45 人,女性 36 人,年龄 40-60 岁)进行了 MRS 分析,并根据急性期的疾病严重程度将他们分为轻度组(17 人)、中度组(36 人)和重度组(28 人)。研究采用了胼胝体上方的二维光谱成像技术,重点研究胆碱(Cho)、肌酸(Cr)和N-乙酰天冬氨酸(NAA)。我们以水为内参,分析了Cho/Cr和NAA/Cr的比率以及绝对浓度。结果显示结果表明,随着疾病严重程度的增加,Cho/Cr 比值越高,而绝对 Cho 和 NAA/Cr 比值在各组间无显著差异。值得注意的是,重症患者的绝对铬和 NAA 水平明显较低。结论:这些研究结果表明,COVID-19 在急性期的严重程度与脑代谢的显著变化有关,表现为 Cho/Cr 比值的升高以及 Cr 和 NAA 水平的降低,反映了恢复后代谢的实质性改变。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Decreased Cerebral Creatine and N-Acetyl Aspartate Concentrations after Severe COVID-19 Infection: A Magnetic Resonance Spectroscopy Study
Background/Objectives: The aim of this study was to evaluate brain metabolism using MR spectroscopy (MRS) after recovery from Coronavirus disease (COVID-19) and to test the impact of disease severity on brain metabolites. Methods: We performed MRS on 81 individuals (45 males, 36 females, aged 40–60), who had normal MRI findings and had recovered from COVID-19, classifying them into mild (17), moderate (36), and severe (28) groups based on disease severity during the acute phase. The study employed two-dimensional spectroscopic imaging above the corpus callosum, focusing on choline (Cho), creatine (Cr), and N-acetylaspartate (NAA). We analyzed Cho/Cr and NAA/Cr ratios as well as absolute concentrations using water as an internal reference. Results: Results indicated that the Cho/Cr ratio was higher with increasing disease severity, while absolute Cho and NAA/Cr ratios showed no significant differences across the groups. Notably, absolute Cr and NAA levels were significantly lower in patients with severe disease. Conclusions: These findings suggest that the severity of COVID-19 during the acute phase is associated with significant changes in brain metabolism, marked by an increase in Cho/Cr ratios and a reduction in Cr and NAA levels, reflecting substantial metabolic alterations post-recovery.
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