小儿心内膜炎--大流行后留下的一块石头

Ancuța Lupu, A. Nedelcu, Paula-Diana Budescu, Elena Jechel, I. Stârcea, O. Frăsinariu, Ileana Ioniuc, Minerva Codruța Bădescu, D. Șalaru, D. Munteanu, Ruxandra Russu, R. Sascău, C. Stătescu, V. Lupu
{"title":"小儿心内膜炎--大流行后留下的一块石头","authors":"Ancuța Lupu, A. Nedelcu, Paula-Diana Budescu, Elena Jechel, I. Stârcea, O. Frăsinariu, Ileana Ioniuc, Minerva Codruța Bădescu, D. Șalaru, D. Munteanu, Ruxandra Russu, R. Sascău, C. Stătescu, V. Lupu","doi":"10.3389/fcimb.2024.1393315","DOIUrl":null,"url":null,"abstract":"Infective endocarditis is a rare disease in children. The etiology is mainly bacterial. However, viral infective endocarditis, possibly related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has also been reported. The pathophysiological principle of the connection between the two entities seems to be attributed to the transient immune deficiency of the body during the infection. Additionally, SARS-CoV-2 is reported in the literature as a direct cardiopathic virus. Therefore, the new coronavirus seems to have the ability to affect both the intact cardiac tissue and the previously damaged one both during the acute episode and at a distance from it. Consequently, we propose to review the main pathophysiological aspects of pediatric cardiac damage caused by SARS-CoV-2. The ultimate goal is to deepen existing knowledge, broaden the horizon of understanding and analysis regarding the systemic damage induced by viral infections, and strengthen an information base from which to start a meta-analysis. Next, we performed a non-systematized screening of the specialized literature with reference to cases of endocarditis in the pediatric population, reported in the period 2020–2023. From the total of articles found, we chose to include in the review a number of 6 case reports, including a number of 7 patients (5 children and 2 adolescents). Analysis of reports suggests that SARS-CoV-2 infection could play a role in the development of endocarditis, either directly through active infection or indirectly through a post-infectious immune response. Also, pre-existing conditions and complex medical history predispose to an increased risk of developing a severe, complicated form of endocarditis. Also, the lack of data on the vaccination history and the failure to categorize the infection depending on the type of antibodies (IgM or IgG) in some studies represent a major bias in the reports. The latter make it difficult to evaluate the influence of vaccination and the impact of acute versus chronic infection on the course of cases.","PeriodicalId":505894,"journal":{"name":"Frontiers in Cellular and Infection Microbiology","volume":"41 32","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Pediatric endocarditis - a stone left after the pandemic cascade\",\"authors\":\"Ancuța Lupu, A. Nedelcu, Paula-Diana Budescu, Elena Jechel, I. Stârcea, O. Frăsinariu, Ileana Ioniuc, Minerva Codruța Bădescu, D. Șalaru, D. Munteanu, Ruxandra Russu, R. Sascău, C. Stătescu, V. Lupu\",\"doi\":\"10.3389/fcimb.2024.1393315\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Infective endocarditis is a rare disease in children. The etiology is mainly bacterial. However, viral infective endocarditis, possibly related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has also been reported. The pathophysiological principle of the connection between the two entities seems to be attributed to the transient immune deficiency of the body during the infection. Additionally, SARS-CoV-2 is reported in the literature as a direct cardiopathic virus. Therefore, the new coronavirus seems to have the ability to affect both the intact cardiac tissue and the previously damaged one both during the acute episode and at a distance from it. Consequently, we propose to review the main pathophysiological aspects of pediatric cardiac damage caused by SARS-CoV-2. The ultimate goal is to deepen existing knowledge, broaden the horizon of understanding and analysis regarding the systemic damage induced by viral infections, and strengthen an information base from which to start a meta-analysis. Next, we performed a non-systematized screening of the specialized literature with reference to cases of endocarditis in the pediatric population, reported in the period 2020–2023. From the total of articles found, we chose to include in the review a number of 6 case reports, including a number of 7 patients (5 children and 2 adolescents). Analysis of reports suggests that SARS-CoV-2 infection could play a role in the development of endocarditis, either directly through active infection or indirectly through a post-infectious immune response. Also, pre-existing conditions and complex medical history predispose to an increased risk of developing a severe, complicated form of endocarditis. Also, the lack of data on the vaccination history and the failure to categorize the infection depending on the type of antibodies (IgM or IgG) in some studies represent a major bias in the reports. The latter make it difficult to evaluate the influence of vaccination and the impact of acute versus chronic infection on the course of cases.\",\"PeriodicalId\":505894,\"journal\":{\"name\":\"Frontiers in Cellular and Infection Microbiology\",\"volume\":\"41 32\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-07-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Frontiers in Cellular and Infection Microbiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3389/fcimb.2024.1393315\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Frontiers in Cellular and Infection Microbiology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3389/fcimb.2024.1393315","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

感染性心内膜炎是一种罕见的儿童疾病。病因主要是细菌。不过,也有报道称病毒性感染性心内膜炎可能与严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)有关。这两种疾病之间的病理生理学原理似乎是由于感染期间机体出现了短暂的免疫缺陷。此外,据文献报道,SARS-CoV-2 是一种直接引起心脏病的病毒。因此,这种新型冠状病毒似乎既能影响完整的心脏组织,也能在急性发作期间或远期影响先前受损的心脏组织。因此,我们建议回顾一下 SARS-CoV-2 导致的小儿心脏损伤的主要病理生理学方面。我们的最终目的是加深对现有知识的了解,拓宽对病毒感染引起的全身性损害的认识和分析视野,并加强信息库,以便开展荟萃分析。接下来,我们对 2020-2023 年期间报道的儿科心内膜炎病例进行了非系统化的专业文献筛选。在所找到的所有文章中,我们选择了 6 篇病例报告,其中包括 7 名患者(5 名儿童和 2 名青少年)。对这些报告的分析表明,SARS-CoV-2 感染可能在心内膜炎的发病过程中起作用,可能是直接通过活动感染,也可能是间接通过感染后的免疫反应。此外,原有的疾病和复杂的病史也会增加患严重的、复杂的心内膜炎的风险。此外,一些研究缺乏疫苗接种史数据,也没有根据抗体类型(IgM 或 IgG)对感染进行分类,这些都是报告中的主要偏差。后者使我们难以评估接种疫苗的影响以及急性感染和慢性感染对病程的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pediatric endocarditis - a stone left after the pandemic cascade
Infective endocarditis is a rare disease in children. The etiology is mainly bacterial. However, viral infective endocarditis, possibly related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has also been reported. The pathophysiological principle of the connection between the two entities seems to be attributed to the transient immune deficiency of the body during the infection. Additionally, SARS-CoV-2 is reported in the literature as a direct cardiopathic virus. Therefore, the new coronavirus seems to have the ability to affect both the intact cardiac tissue and the previously damaged one both during the acute episode and at a distance from it. Consequently, we propose to review the main pathophysiological aspects of pediatric cardiac damage caused by SARS-CoV-2. The ultimate goal is to deepen existing knowledge, broaden the horizon of understanding and analysis regarding the systemic damage induced by viral infections, and strengthen an information base from which to start a meta-analysis. Next, we performed a non-systematized screening of the specialized literature with reference to cases of endocarditis in the pediatric population, reported in the period 2020–2023. From the total of articles found, we chose to include in the review a number of 6 case reports, including a number of 7 patients (5 children and 2 adolescents). Analysis of reports suggests that SARS-CoV-2 infection could play a role in the development of endocarditis, either directly through active infection or indirectly through a post-infectious immune response. Also, pre-existing conditions and complex medical history predispose to an increased risk of developing a severe, complicated form of endocarditis. Also, the lack of data on the vaccination history and the failure to categorize the infection depending on the type of antibodies (IgM or IgG) in some studies represent a major bias in the reports. The latter make it difficult to evaluate the influence of vaccination and the impact of acute versus chronic infection on the course of cases.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信