多形性胶质母细胞瘤的化学动力疗法与展望

Zia Ullah, Yasir Abbas, Jingsi Gu, Sai Ko Soe, Shubham Roy, Tingting Peng, B. Guo
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引用次数: 0

摘要

多形性胶质母细胞瘤(GBM)是一个潜在的公共卫生问题,是先进科学领域亟待解决的巨大挑战。基于芬顿反应的化学动力疗法(CDT)已成为治疗多形性胶质母细胞瘤的最先进疗法。然而,穿过血脑屏障(BBB)到达 GBM 又是一场无休止的马拉松。本综述阐述了 BBB 的生理学原理,以了解穿越这些潜在屏障治疗 GBM 的机制。此外,还讨论了如何设计基于芬顿的纳米材料,以便在肿瘤区域产生活性氧来消灭癌细胞。为了有效靶向肿瘤,人们还探索了可通过神经血管转运通道穿过 BBB 的生物纳米材料。为了克服无机纳米材料造成的神经毒性,系统地总结了如何使用生物相容性和有效肿瘤靶向能力均得到增强的智能纳米试剂来提高 CDT 的效率。最后,还展示了基于 Fenton 的智能纳米系统在 CDT 之外的多模式治疗方法方面取得的进展。希望这篇系统性综述能让人们更好地了解基于芬顿的 CDT 并深入了解 GBM 的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Chemodynamic Therapy of Glioblastoma Multiforme and Perspectives
Glioblastoma multiforme (GBM), a potential public health issue, is a huge challenge for the advanced scientific realm to solve. Chemodynamic therapy (CDT) based on the Fenton reaction emerged as a state-of-the-art therapeutic modality to treat GBM. However, crossing the blood–brain barrier (BBB) to reach the GBM is another endless marathon. In this review, the physiology of the BBB has been elaborated to understand the mechanism of crossing these potential barriers to treat GBM. Moreover, the designing of Fenton-based nanomaterials has been discussed for the production of reactive oxygen species in the tumor area to eradicate the cancer cells. For effective tumor targeting, biological nanomaterials that can cross the BBB via neurovascular transport channels have also been explored. To overcome the neurotoxicity caused by inorganic nanomaterials, the use of smart nanoagents having both enhanced biocompatibility and effective tumor targeting ability to enhance the efficiency of CDT are systematically summarized. Finally, the advancements in intelligent Fenton-based nanosystems for a multimodal therapeutic approach in addition to CDT are demonstrated. Hopefully, this systematic review will provide a better understanding of Fenton-based CDT and insight into GBM treatment.
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