使用α-葡萄糖苷酶抑制剂研究布基纳法索大戟科植物大戟的提取物的抗糖尿病活性

International Research Journal of Pure and Applied Chemistry Pub Date : 2024-07-16 DOI:10.9734/irjpac/2024/v25i4865

Y. Karanga, Têeda Hamidou Ganamé, Wende-Konté Hazael Conania Nikiema, I. Tapsoba

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引用次数: 0

摘要

大戟（Euphorbia hirta L.）是一种草本植物，在传统医学中被用来治疗多种疾病。在本研究中，研究了大戟科植物水醇提取物的不同馏分对α-葡萄糖苷酶抑制活性的抗糖尿病特性。采用 Folin-Ciocalteu 和 AlCl3 方法进行的化学筛选表明，乙酸乙酯（AcOET）和丁醇（BuOH）提取物中的酚类化合物含量分别为 432.687 ± 1.832 µg 和 332.433 ± 1.255 µg GAE/mg。同样的提取物还含有大量总黄酮，估计分别为 417.850 ± 15.941 µg 和 227.640 ± 2.657 μg QE/mg。抗糖尿病活性表明，AcOET 和 BuOH 对α-葡萄糖苷酶的酶活性具有非常显著的抑制潜力，与阿卡波糖（IC50 = 214.825 ± 3.816 μg/mL）相比，其 IC50 值分别为 1.295 ± 0.035 μg/mL 和 2.188 ± 0.204 μg/mL。

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Anti-Diabetic Activities of the Extracts from Euphorbia hirta L. (Euphorbiaceae) Specie found in Burkina Faso Using α-Glucosidase Inhibitor

Euphorbia hirta L. is an herbaceous plant used in traditional medicine to treat several diseases. In the present work, different fractions of Euphorbia hirta L. hydroalcoholic extract were investigated for their anti-diabetic properties on α-glucosidase’s inhibition activities. Chemical screening realized following Folin-Ciocalteu and AlCl3 methods showed that ethyl acetate (AcOET) and butanol (BuOH) extracts contain 432.687 ± 1.832 µg and 332.433 ± 1.255 µg GAE/mg of extract for phenolic compounds. The same extracts contained high levels of total flavonoids estimated at 417.850 ± 15.941 µg and 227.640 ± 2.657 μg QE/mg of extract respectively. The anti-diabetic activities revealed that AcOET and BuOH have a very significant inhibitory potential on the enzymatic activity of α-glucosidase with an IC50 values of 1.295 ± 0.035 μg/mL and 2.188 ± 0.204 μg/mL respectively compared to acarbose (IC50 = 214.825 ± 3.816 μg/mL).

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International Research Journal of Pure and Applied Chemistry

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