天然倍半萜在治疗肝细胞癌方面的研究进展

Xiaodong Wang, Fancheng Meng, Jingxin Mao
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引用次数: 0

摘要

肝细胞癌是消化道常见的恶性肿瘤之一,因其发病率高、侵袭性强、转移性大、预后差等特点,严重威胁着患者的生命安全。目前,预防和治疗 HCC 的主要方法包括药物治疗、手术治疗和介入治疗,但患者经常会遇到一些特殊的不良反应或副作用。许多中药能改善肝功能,减少肝癌复发,具有多靶点、多途径、多成分、多层次的作用模式,在治疗 HCC 方面具有独特的优势。倍半萜类化合物是一类天然产物,广泛存在于自然界中,具有良好的抗肿瘤活性,其中许多化合物在治疗 HCC 方面具有良好的潜力。本文综述了天然倍半萜类化合物对HCC的抗肿瘤活性、天然资源、药理机制等,为防治HCC提供理论依据,并全面了解其开发临床新药的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Progress of natural sesquiterpenoids in the treatment of hepatocellular carcinoma
Hepatocellular carcinoma is one of the common malignant tumors of digestive tract, which seriously threatens the life of patients due to its high incidence rate, strong invasion, metastasis, and prognosis. At present, the main methods for preventing and treating HCC include medication, surgery, and intervention, but patients frequently encounter with specific adverse reactions or side effects. Many Traditional Chinese medicine can improve liver function, reduce liver cancer recurrence and have unique advantages in the treatment of HCC because of their acting mode of multi-target, multi-pathway, multi-component, and multi-level. Sesquiterpenoids, a class of natural products which are widely present in nature and exhibit good anti-tumor activity, and many of them possess good potential for the treatment of HCC. This article reviewed the anti-tumor activities, natural resources, pharmacological mechanism of natural sesquiterpenoids against HCC, providing the theoretical basis for the prevention and treatment of HCC and a comprehensive understanding of their potential for development of new clinical drugs.
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