不锈钢 316L 上二氧化钛纳米粒子涂层的制备及其骨科应用评估

Manjit Singh Jadon, Sandeep Kumar
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摘要

本研究旨在探讨二氧化钛(TiO2)纳米粒子涂层在不锈钢 316L (SS 316L)骨科植入物上的功效,以增强其生物相容性、骨结合性和耐用性。通过水热法合成了二氧化钛纳米粒子,并利用 X 射线衍射 (XRD)、傅立叶变换红外光谱 (FTIR)、扫描电子显微镜 (SEM) 和能量色散 X 射线分析 (EDX) 等技术对其成分、结晶度和形态进行了广泛表征,并通过元素图谱进行了证实。扫描电子显微镜和 XRD 分析表明,合成的纳米粒子呈球形,平均尺寸约为 23 纳米。利用旋涂技术将合成的 TiO2 纳米粒子均匀地涂在 SS 316L 基质上,这一点已通过扫描电镜图像得到证实。使用 MTT(3-(4, 5-二甲基噻唑-2-基)-2, 5-二苯基溴化四氮唑)测定法对 NIH-3T3 小鼠胚胎成纤维细胞系评估了合成的 TiO2 纳米粒子以及未涂层和涂层 TiO2 纳米粒子的 SS 316L 基底的细胞活力。结果表明,与未涂覆的 SS 316L 基质相比,涂覆了 TiO2 纳米粒子的 SS 316L 基质的细胞存活率显著提高了 22.87%。在 30N 负载条件下,使用盘上球摩擦仪在不同转速(即 150 rpm、300 rpm 和 450 rpm)下评估磨损和摩擦阻力,持续时间为五分钟。总的结果表明,TiO2 纳米粒子涂层的 SS 316L 基材在矫形外科应用中的性能得到了大幅提高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fabrication of TiO2 Nanoparticle Coating on Stainless Steel 316L and Its Assessment for Orthopaedic Applications
The study aims to investigate the efficacy of titanium dioxide (TiO2) nanoparticle coating on stainless steel 316L (SS 316L) orthopaedic implants to enhance their biocompatibility, osseointegration, and durability. The TiO2 nanoparticles were synthesized via the hydrothermal method and extensively characterized for composition, crystallinity, and morphology using techniques such as X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), corroborated by elemental mapping. SEM and XRD analyses revealed the synthesized nanoparticles have a spherical shape and an average size of approximately 23 nanometres. The synthesized TiO2 nanoparticles were uniformly coated on SS 316L substrates using the spin coating technique, as confirmed by SEM images. Cell viability of the synthesized TiO2 nanoparticles, as well as uncoated and TiO2 nanoparticle-coated SS 316L substrates, was evaluated using the MTT (3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide) assay against the NIH-3T3 mouse embryonic fibroblast cell line. The results demonstrated that the TiO2 nanoparticle-coated SS 316L substrate showed a significant increase of 22.87% in cell viability as compared to the uncoated SS 316L substrate. A ball-on-disc tribometer was employed to assess wear and friction resistance at various speeds, viz., 150 rpm, 300 rpm, and 450 rpm, under 30N load conditions for five minutes. The results collectively indicate a substantial improvement in the performance of TiO2 nanoparticle-coated SS 316L substrates for orthopaedic applications.
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