{"title":"开发与微流控通道集成的导电碳基交错电极阵列,用于血糖传感","authors":"Anindya Bose, Sarthak Sengupta, Sayori Biswas","doi":"10.1108/sr-03-2024-0282","DOIUrl":null,"url":null,"abstract":"\nPurpose\nThis study aims to provide a microfluidic blood glucose sensing platform based on integrated interdigitated electrode arrays (IDEAs) on a flexible quartz glass substrate, adhering closely to pertinent electrochemical characterizations.\n\n\nDesign/methodology/approach\nSensors are the key elements of the modern electronics era through which all the possible physical quantities can be detected and converted into their equivalent electrical form and processed further. But to make the sensing environment better, various types of innovative architectures are being developed nowadays and among them interdigitated electrodes are quite remarkable in terms of their sensing capability. They are a well-qualified candidate in the field of gas sensing and biosensing, but even their sensitivities are getting saturated due to their physical dimensions. Most of the thin film IDEAs fabricated by conventional optical lithographic techniques do not possess a high surface-to-volume ratio to detect the target specified and that reduces their sensitivity factor. In this context, a classic conductive carbon-based highly sensitive three dimensional (3D) IDEA-enabled biosensing system has been conceived on a transparent and flexible substrate to measure the amount of glucose concentration present in human blood. 3D IDEA possesses a way better capacitive sensing behavior compared to conventional thin film microcapacitive electrodes. To transmit the target biological analyte sample property for the detection purpose to the interdigitated array-based sensing platform, the design of a microfluidic channel is initiated on the same substrate. The complex 3D Inter Digital array structure improves the overall capacitance of the entire sensing platform and the reactive surface area as well. The manufactured integrated device displays a decent value of sensitivity in the order of 5.6 µA mM−1 cm−2.\n\n\nFindings\nDevelopment of a low-cost array-based integrated and highly flexible microfluidic biochip to extract the quantity of glucose present in human blood.\n\n\nOriginality/value\nPotential future research opportunities in the realm of integrated miniaturized, low-cost smart biosensing systems may arise from this study.\n","PeriodicalId":49540,"journal":{"name":"Sensor Review","volume":null,"pages":null},"PeriodicalIF":1.6000,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Development of conductive carbon-based interdigitated electrode array integrated with microfluidic channel for blood glucose sensing\",\"authors\":\"Anindya Bose, Sarthak Sengupta, Sayori Biswas\",\"doi\":\"10.1108/sr-03-2024-0282\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\nPurpose\\nThis study aims to provide a microfluidic blood glucose sensing platform based on integrated interdigitated electrode arrays (IDEAs) on a flexible quartz glass substrate, adhering closely to pertinent electrochemical characterizations.\\n\\n\\nDesign/methodology/approach\\nSensors are the key elements of the modern electronics era through which all the possible physical quantities can be detected and converted into their equivalent electrical form and processed further. But to make the sensing environment better, various types of innovative architectures are being developed nowadays and among them interdigitated electrodes are quite remarkable in terms of their sensing capability. They are a well-qualified candidate in the field of gas sensing and biosensing, but even their sensitivities are getting saturated due to their physical dimensions. Most of the thin film IDEAs fabricated by conventional optical lithographic techniques do not possess a high surface-to-volume ratio to detect the target specified and that reduces their sensitivity factor. In this context, a classic conductive carbon-based highly sensitive three dimensional (3D) IDEA-enabled biosensing system has been conceived on a transparent and flexible substrate to measure the amount of glucose concentration present in human blood. 3D IDEA possesses a way better capacitive sensing behavior compared to conventional thin film microcapacitive electrodes. To transmit the target biological analyte sample property for the detection purpose to the interdigitated array-based sensing platform, the design of a microfluidic channel is initiated on the same substrate. The complex 3D Inter Digital array structure improves the overall capacitance of the entire sensing platform and the reactive surface area as well. The manufactured integrated device displays a decent value of sensitivity in the order of 5.6 µA mM−1 cm−2.\\n\\n\\nFindings\\nDevelopment of a low-cost array-based integrated and highly flexible microfluidic biochip to extract the quantity of glucose present in human blood.\\n\\n\\nOriginality/value\\nPotential future research opportunities in the realm of integrated miniaturized, low-cost smart biosensing systems may arise from this study.\\n\",\"PeriodicalId\":49540,\"journal\":{\"name\":\"Sensor Review\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-07-18\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Sensor Review\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1108/sr-03-2024-0282\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INSTRUMENTS & INSTRUMENTATION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Sensor Review","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1108/sr-03-2024-0282","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INSTRUMENTS & INSTRUMENTATION","Score":null,"Total":0}
引用次数: 0
摘要
本研究旨在提供一种基于柔性石英玻璃基底上的集成交错电极阵列(IDEA)的微流体血糖传感平台,该平台与相关的电化学特性密切相关。设计/方法/途径传感器是现代电子时代的关键要素,通过它可以检测所有可能的物理量,并将其转换为等效的电形式,然后进行进一步处理。但是,为了改善传感环境,目前正在开发各种类型的创新结构,其中相互咬合的电极在传感能力方面相当出色。它们是气体传感和生物传感领域的理想选择,但由于其物理尺寸的限制,其灵敏度已趋于饱和。大多数通过传统光学平版印刷技术制造的薄膜 IDEA 都不具备很高的表面体积比来检测指定目标,这就降低了它们的灵敏度系数。在这种情况下,我们在透明柔性基底上设计了一种经典的导电碳基高灵敏三维(3D)IDEA 生物传感系统,用于测量人体血液中的葡萄糖浓度。与传统的薄膜微电容电极相比,三维 IDEA 具有更好的电容传感性能。为了将用于检测目的的目标生物分析样本特性传输到基于插值阵列的传感平台,在同一基底上启动了微流体通道的设计。复杂的三维数字间阵列结构提高了整个传感平台的整体电容和反应表面积。研究结果开发出一种基于阵列的低成本集成高柔性微流控生物芯片,用于提取人体血液中的葡萄糖含量。
Development of conductive carbon-based interdigitated electrode array integrated with microfluidic channel for blood glucose sensing
Purpose
This study aims to provide a microfluidic blood glucose sensing platform based on integrated interdigitated electrode arrays (IDEAs) on a flexible quartz glass substrate, adhering closely to pertinent electrochemical characterizations.
Design/methodology/approach
Sensors are the key elements of the modern electronics era through which all the possible physical quantities can be detected and converted into their equivalent electrical form and processed further. But to make the sensing environment better, various types of innovative architectures are being developed nowadays and among them interdigitated electrodes are quite remarkable in terms of their sensing capability. They are a well-qualified candidate in the field of gas sensing and biosensing, but even their sensitivities are getting saturated due to their physical dimensions. Most of the thin film IDEAs fabricated by conventional optical lithographic techniques do not possess a high surface-to-volume ratio to detect the target specified and that reduces their sensitivity factor. In this context, a classic conductive carbon-based highly sensitive three dimensional (3D) IDEA-enabled biosensing system has been conceived on a transparent and flexible substrate to measure the amount of glucose concentration present in human blood. 3D IDEA possesses a way better capacitive sensing behavior compared to conventional thin film microcapacitive electrodes. To transmit the target biological analyte sample property for the detection purpose to the interdigitated array-based sensing platform, the design of a microfluidic channel is initiated on the same substrate. The complex 3D Inter Digital array structure improves the overall capacitance of the entire sensing platform and the reactive surface area as well. The manufactured integrated device displays a decent value of sensitivity in the order of 5.6 µA mM−1 cm−2.
Findings
Development of a low-cost array-based integrated and highly flexible microfluidic biochip to extract the quantity of glucose present in human blood.
Originality/value
Potential future research opportunities in the realm of integrated miniaturized, low-cost smart biosensing systems may arise from this study.
期刊介绍:
Sensor Review publishes peer reviewed state-of-the-art articles and specially commissioned technology reviews. Each issue of this multidisciplinary journal includes high quality original content covering all aspects of sensors and their applications, and reflecting the most interesting and strategically important research and development activities from around the world. Because of this, readers can stay at the very forefront of high technology sensor developments.
Emphasis is placed on detailed independent regular and review articles identifying the full range of sensors currently available for specific applications, as well as highlighting those areas of technology showing great potential for the future. The journal encourages authors to consider the practical and social implications of their articles.
All articles undergo a rigorous double-blind peer review process which involves an initial assessment of suitability of an article for the journal followed by sending it to, at least two reviewers in the field if deemed suitable.
Sensor Review’s coverage includes, but is not restricted to:
Mechanical sensors – position, displacement, proximity, velocity, acceleration, vibration, force, torque, pressure, and flow sensors
Electric and magnetic sensors – resistance, inductive, capacitive, piezoelectric, eddy-current, electromagnetic, photoelectric, and thermoelectric sensors
Temperature sensors, infrared sensors, humidity sensors
Optical, electro-optical and fibre-optic sensors and systems, photonic sensors
Biosensors, wearable and implantable sensors and systems, immunosensors
Gas and chemical sensors and systems, polymer sensors
Acoustic and ultrasonic sensors
Haptic sensors and devices
Smart and intelligent sensors and systems
Nanosensors, NEMS, MEMS, and BioMEMS
Quantum sensors
Sensor systems: sensor data fusion, signals, processing and interfacing, signal conditioning.