Mohd Fazl Ul Haq, Gowhar Aziz Bhat, Munir Ah Wani, Ajaz Ah Malik, Mohd Israr Ul Haq, Mohd Ehsan Ul Haq
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We aimed to study the outcomes of these obstructed colorectal cancers requiring emergency intervention and compare it with nonobstructed cancers.</p><p><strong>Materials and methods: </strong>In our observational comparative study, patients were divided into groups on basis of their presentation and site of lesion: nonobstructing colon group/obstructing colon group nonobstructing rectum group/obstructing rectum group.</p><p><strong>Results: </strong>A total of 232 patients with known modes of presentation between 2015 and 2018 were included; 144 colonic, 88 rectal carcinomas with 71 being completely obstructive ones. Our study showed higher recurrence in obstructive groups with local recurrence being more common. The median interval for recurrence was early in obstructive group (<i>p</i> < 0.001*). The overall 5-year survival rates were better in Nonobstructing colon group, (<i>p</i> = -0.046* in OR vs NOR) (<i>p</i> = -0.031* in OC vs NOC). 5-year disease-free survival rates statistically insignificant (<i>p</i> = 0.203 in NOC and OC groups), (<i>p</i> = 0.307 in NOR and OR groups). Immediate post-op, complications except for SSI, there was no significant difference between the two groups. Our study showed higher proportion of R0 resection in NOC groups as compared with obstructive groups (<i>p</i> = 0.021* in in OC vs NOC and <i>p</i> = 0.037* in OR vs NOR) with better lymph node retrieval in NOC groups.</p><p><strong>Conclusion: </strong>On comparing outcome of patients who had completed multi-modal therapy in both groups, there was significantly better outcome for patients who have presented without obstruction.</p><p><strong>How to cite this article: </strong>Ul Haq MF, Bhat GA, Wani MA, <i>et al</i>. Outcome of Obstructing vs Nonobstructing Colorectal Carcinomas: Comparative Study at Tertiary Care Hospital in Kashmir. Euroasian J Hepato-Gastroenterol 2024;14(1):75-80.</p>","PeriodicalId":516317,"journal":{"name":"Euroasian journal of hepato-gastroenterology","volume":"14 1","pages":"75-80"},"PeriodicalIF":0.0000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11249899/pdf/","citationCount":"0","resultStr":"{\"title\":\"Outcome of Obstructing vs Nonobstructing Colorectal Carcinomas: Comparative Study at Tertiary Care Hospital in Kashmir.\",\"authors\":\"Mohd Fazl Ul Haq, Gowhar Aziz Bhat, Munir Ah Wani, Ajaz Ah Malik, Mohd Israr Ul Haq, Mohd Ehsan Ul Haq\",\"doi\":\"10.5005/jp-journals-10018-1421\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Colorectal cancer (CRC) is the commonly diagnosed malignancy presenting either in obstruction or without obstruction. Bowel obstruction (BO) is usually a complication of advanced cancer, significantly reducing the quality of life. We aimed to study the outcomes of these obstructed colorectal cancers requiring emergency intervention and compare it with nonobstructed cancers.</p><p><strong>Materials and methods: </strong>In our observational comparative study, patients were divided into groups on basis of their presentation and site of lesion: nonobstructing colon group/obstructing colon group nonobstructing rectum group/obstructing rectum group.</p><p><strong>Results: </strong>A total of 232 patients with known modes of presentation between 2015 and 2018 were included; 144 colonic, 88 rectal carcinomas with 71 being completely obstructive ones. Our study showed higher recurrence in obstructive groups with local recurrence being more common. The median interval for recurrence was early in obstructive group (<i>p</i> < 0.001*). The overall 5-year survival rates were better in Nonobstructing colon group, (<i>p</i> = -0.046* in OR vs NOR) (<i>p</i> = -0.031* in OC vs NOC). 5-year disease-free survival rates statistically insignificant (<i>p</i> = 0.203 in NOC and OC groups), (<i>p</i> = 0.307 in NOR and OR groups). Immediate post-op, complications except for SSI, there was no significant difference between the two groups. Our study showed higher proportion of R0 resection in NOC groups as compared with obstructive groups (<i>p</i> = 0.021* in in OC vs NOC and <i>p</i> = 0.037* in OR vs NOR) with better lymph node retrieval in NOC groups.</p><p><strong>Conclusion: </strong>On comparing outcome of patients who had completed multi-modal therapy in both groups, there was significantly better outcome for patients who have presented without obstruction.</p><p><strong>How to cite this article: </strong>Ul Haq MF, Bhat GA, Wani MA, <i>et al</i>. Outcome of Obstructing vs Nonobstructing Colorectal Carcinomas: Comparative Study at Tertiary Care Hospital in Kashmir. 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引用次数: 0
摘要
背景：结肠直肠癌（CRC）是一种常见的恶性肿瘤，可表现为梗阻或无梗阻。肠梗阻（BO）通常是晚期癌症的并发症，会大大降低患者的生活质量。我们旨在研究这些需要紧急干预的梗阻性结直肠癌的治疗效果，并将其与非梗阻性结直肠癌进行比较：在我们的观察比较研究中，根据患者的表现和病变部位将其分为几组：无梗阻结肠组/梗阻结肠组 无梗阻直肠组/梗阻直肠组：共纳入2015年至2018年间已知表现方式的232例患者，其中结肠癌144例，直肠癌88例，71例为完全梗阻性直肠癌。我们的研究显示，梗阻组复发率较高，局部复发更为常见。梗阻组复发的中位间隔时间较早（P < 0.001*）。非梗阻性结肠组的总体 5 年生存率更高（OR 与 NOR 相比，p = -0.046*）（OC 与 NOC 相比，p = -0.031*）。5年无病生存率无统计学意义（NOC组和OC组p = 0.203），（NOR组和OR组p = 0.307）。除 SSI 外，两组术后并发症无显著差异。我们的研究显示，与阻塞组相比，NOC 组的 R0 切除率更高（OC 组与 NOC 组的 P = 0.021*，OR 组与 NOR 组的 P = 0.037*），NOC 组的淋巴结取材率更高：结论：比较两组完成多模式治疗的患者的疗效，无梗阻组患者的疗效明显更好：Ul Haq MF, Bhat GA, Wani MA, et al. Obstructing vs Nonobstructing Colorectal Carcinomas：克什米尔三级医院比较研究》。Euroasian J Hepato-Gastroenterol 2024;14(1):75-80.
Outcome of Obstructing vs Nonobstructing Colorectal Carcinomas: Comparative Study at Tertiary Care Hospital in Kashmir.
Background: Colorectal cancer (CRC) is the commonly diagnosed malignancy presenting either in obstruction or without obstruction. Bowel obstruction (BO) is usually a complication of advanced cancer, significantly reducing the quality of life. We aimed to study the outcomes of these obstructed colorectal cancers requiring emergency intervention and compare it with nonobstructed cancers.
Materials and methods: In our observational comparative study, patients were divided into groups on basis of their presentation and site of lesion: nonobstructing colon group/obstructing colon group nonobstructing rectum group/obstructing rectum group.
Results: A total of 232 patients with known modes of presentation between 2015 and 2018 were included; 144 colonic, 88 rectal carcinomas with 71 being completely obstructive ones. Our study showed higher recurrence in obstructive groups with local recurrence being more common. The median interval for recurrence was early in obstructive group (p < 0.001*). The overall 5-year survival rates were better in Nonobstructing colon group, (p = -0.046* in OR vs NOR) (p = -0.031* in OC vs NOC). 5-year disease-free survival rates statistically insignificant (p = 0.203 in NOC and OC groups), (p = 0.307 in NOR and OR groups). Immediate post-op, complications except for SSI, there was no significant difference between the two groups. Our study showed higher proportion of R0 resection in NOC groups as compared with obstructive groups (p = 0.021* in in OC vs NOC and p = 0.037* in OR vs NOR) with better lymph node retrieval in NOC groups.
Conclusion: On comparing outcome of patients who had completed multi-modal therapy in both groups, there was significantly better outcome for patients who have presented without obstruction.
How to cite this article: Ul Haq MF, Bhat GA, Wani MA, et al. Outcome of Obstructing vs Nonobstructing Colorectal Carcinomas: Comparative Study at Tertiary Care Hospital in Kashmir. Euroasian J Hepato-Gastroenterol 2024;14(1):75-80.
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