FGF21 在肥胖与非酒精性脂肪肝之间相互作用中的作用:综述。

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Cristina Elena Negroiu, Robertina Iulia Tudoraşcu, Maria Cristina Beznă, Adrian Ionuţ Ungureanu, Sorina Octavia Honţaru, Suzana Dănoiu
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引用次数: 0

摘要

肥胖症是当代社会面临的一个日益严峻的挑战,它增加了罹患各种代谢性疾病的风险,如血脂异常、心血管疾病、非酒精性脂肪肝、2 型糖尿病和某些类型的癌症。目前针对肥胖症的一系列治疗干预措施仍显不足,这促使人们迫切要求获得更有效的新型治疗方法。鉴于成纤维细胞生长因子 21(FGF21)对脂质、碳水化合物和能量代谢的显著而多样的影响,科学界已将注意力转向它。本综述旨在深入探讨成纤维细胞生长因子21的各个方面,包括其发现、合成、功能作用以及作为生物标记物和治疗剂的潜力,并特别关注其对非酒精性脂肪肝的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The role of FGF21 in the interplay between obesity and non-alcoholic fatty liver disease: a narrative review.

Obesity poses a significant and escalating challenge in contemporary society, increasing the risk of developing various metabolic disorders such as dyslipidemia, cardiovascular diseases, non-alcoholic fatty liver disease (NAFLD), type 2 diabetes, and certain types of cancer. The current array of therapeutic interventions for obesity remains insufficient, prompting a pressing demand for novel and more effective treatments. In response, scientific attention has turned to the fibroblast growth factor 21 (FGF21) due to its remarkable and diverse impacts on lipid, carbohydrate, and energy metabolism. This comprehensive review aims to delve into the multifaceted aspects of FGF21, encompassing its discovery, synthesis, functional roles, and potential as a biomarker and therapeutic agent, with a specific focus on its implications for NAFLD.

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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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