罗马尼亚西部地区白血病患者的经典和分子细胞遗传学研究结果。

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Cristina Annemari Popa, Nicoleta Ioana Andreescu, Teodora Smaranda Arghirescu, Carmen Angela Maria Petrescu, Cristian Marius Jincă, Emil Florin Huţ, Răzvan Gabriel Drăgoi, George Puenea, Daniel Popa
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引用次数: 0

摘要

急性淋巴细胞白血病(ALL)是儿童期最常见的白血病类型,在成人中较为罕见,而急性髓细胞白血病(AML)在儿童中较少见,在老年人中较为常见。本研究旨在介绍我们使用经典和分子细胞遗传学方法诊断白血病的经验。该研究于2009年至2019年期间在罗马尼亚蒂米什瓦拉市路易斯-楚尔卡努儿童急救医院肿瘤血液学部经典和分子遗传实验室进行。研究小组包括337名儿童和成人,评估时间为2009年至2019年。通过使用传统和分子细胞遗传学技术,发现的细胞遗传学异常包括35个染色体数字异常、10个(9;22)(q34;q11) [4个ALL、1个AML、5个慢性粒细胞白血病(CML)]易位、9个(15;17)(q24;q21)易位、3个(14;14)(q11;q32)易位、2个(4;11)(q21;q23)易位、一个(1;14)(p32;q11)易位、一个(7;14)(qter;q11)易位、一个(8;21)(q22;q22)易位、一个(9;14)(p12;q32)易位、七个 MLL 基因重排和两个核心结合因子亚基 beta∕ 肌球蛋白重链 11(CBFB∕MYH11)基因重排。使用常规和分子细胞遗传学分析是急性白血病患者最重要的预后指标之一,可确定疾病的不同生物学亚型并选择适当的治疗方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Classic and molecular cytogenetic findings in leukemia patients from the Western part of Romania.

Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in childhood and rare in adults, while acute myeloid leukemia (AML) is less common in children and more common in older adults. The aim of the study was to present our experience for the diagnostic of leukemia by using the classic and molecular cytogenetic methods. The study was conducted between 2009 and 2019 within the Classic and Molecular Genetic Laboratory of the Oncohematology Department from the Louis Ţurcanu Emergency Hospital for Children, Timişoara, Romania. The study group included 337 children and adults, evaluated between 2009 and 2019. By using the conventional and molecular cytogenetic technique, the cytogenetic anomalies found were 35 numerical chromosomal abnormalities, 10 (9;22)(q34;q11) [four ALL, one AML, five chronic myeloid leukemia (CML)] translocations, nine (15;17)(q24;q21) translocations, three (14;14)(q11;q32) translocations, two (4;11)(q21;q23) translocations, one (1;14)(p32;q11) translocation, one (7;14)(qter;q11) translocation, one (8;21)(q22;q22) translocation, one (9;14)(p12;q32) translocation, seven rearrangements of the MLL gene and two rearrangements of the core-binding factor subunit beta∕myosin heavy chain 11 (CBFB∕MYH11) gene. The use of conventional and molecular cytogenetic analysis is one of the most important prognostic indicators in acute leukemia patients, allowing the identification of biologically distinct subtypes of disease and selection of appropriate treatment approaches.

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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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