Irreversibility of stochastic state transitions in Langevin systems with odd elasticity.

Active microscopic objects, such as an enzyme molecule, are modeled by the Langevin system with the odd elasticity, in which energy injection from the substrate to the enzyme is described by the antisymmetric part of the elastic matrix. By applying the Onsager-Machlup integral and large deviation theory to the Langevin system with odd elasticity, we can calculate the cumulant generating function of the irreversibility of the state transition. For an N-component system, we obtain a formal expression of the cumulant generating function and demonstrate that the oddness λ, which quantifies the antisymmetric part of the elastic matrix, leads to higher-order cumulants that do not appear in a passive elastic system. To demonstrate the effect of the oddness under the concrete parameter, we analyze the simplest two-component system and obtain the optimal transition path and cumulant generating function. The cumulants obtained from expansion of the cumulant generating function increase monotonically with the oddness. This implies that the oddness causes the uncertainty of stochastic state transitions.