用于软组织再生的具有增强疏水性的聚乳酸混合明胶基纳米纤维垫。

Q3 Engineering
Nasima Akter Mukta, Samina Ahmed, A M Sarwaruddin Chowdhury, M Nuruzzaman Khan, Md Sahadat Hossain, Gawsia W Chowdhury, Papia Haque
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引用次数: 0

摘要

伤口愈合需要大量的水分,这样才能更快地恢复。完全疏水或亲水的生物材料不适合用于受伤部位的细胞生长。该研究旨在利用疏水性聚乳酸溶液和亲水性明胶溶液的混合物制备纳米纤维支架。使用表面活性剂实现了混合溶液的稳定性,并用该溶液制成了电纺纳米纤维支架。在电导率、粘度和 FESEM 分析的帮助下,确定了明胶和聚乳酸的最佳成分,以制成纤维直径均匀的支架。TGA、DSC 和 XRD 分析对最佳支架进行了表征。最佳样品的水接触角为 27°。混合支架对细胞无毒,在大鼠模型试验中,伤口愈合速度比聚乳酸支架或明胶支架单独使用时快 30%。组织学检测也证明混合支架是一种令人鼓舞的组织再生材料。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PLA blended gelatine-based nanofibrous mats with enhanced hydrophobicity for soft tissue regeneration.

Wound healing requires a substantial amount of moisture for faster recovery. Completely hydrophobic or hydrophilic biomaterials are not suitable to be applied for cell growth in wounded areas. The study aimed to prepare a nanofibrous scaffold from the blend of a solution of hydrophobic PLA and a solution of hydrophilic gelatine. The stability of the blend was achieved using a surfactant and an electrospun nanofibrous scaffold was made out of the solution. The optimum composition of gelatine and PLA to make a scaffold of uniform fibre diameter was achieved with the help of conductivity, viscosity and FESEM analysis. The optimum scaffold was characterised by TGA, DSC and XRD analysis. The water contact angle of the optimum sample was observed at 27°. The blended scaffold was found non-toxic to cells and showed a 30% faster healing of wounds in the rat model test compared to the healing rate of the PLA scaffold or the gelatine scaffold alone. The histological assay also supported the blend scaffold as an encouraging material for tissue regeneration.

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来源期刊
Journal of Medical Engineering and Technology
Journal of Medical Engineering and Technology Engineering-Biomedical Engineering
CiteScore
4.60
自引率
0.00%
发文量
77
期刊介绍: The Journal of Medical Engineering & Technology is an international, independent, multidisciplinary, bimonthly journal promoting an understanding of the physiological processes underlying disease processes and the appropriate application of technology. Features include authoritative review papers, the reporting of original research, and evaluation reports on new and existing techniques and devices. Each issue of the journal contains a comprehensive information service which provides news relevant to the world of medical technology, details of new products, book reviews, and selected contents of related journals.
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