镁用于疾病治疗和预防：新兴机制和机遇。

IF 13.9 1区医学 Q1 PHARMACOLOGY & PHARMACY

Trends in pharmacological sciences Pub Date : 2024-08-01 Epub Date: 2024-07-16 DOI:10.1016/j.tips.2024.06.004

Qi Gao, Onur Cil

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引用次数: 0

摘要

镁（Mg2+）是预防和治疗疾病的常用膳食补充剂。然而，由于早期研究结果相互矛盾，Mg2+ 对大多数疾病的疗效和作用机制一直存在争议。最近的临床和临床前研究为利用 Mg2+ 治疗和预防影响不同器官系统的疾病提供了新的见解。在这篇综述中，我们概述了 Mg2+ 医学益处的最新临床证据和争议。此外，我们还批判性地讨论了在了解 Mg2+ 作用机制方面的最新进展，这些进展有助于开发新型靶向疗法。

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Magnesium for disease treatment and prevention: emerging mechanisms and opportunities.

Magnesium (Mg²⁺) is a commonly used dietary supplement for the prevention and treatment of diseases. However, the efficacy and mechanisms of action of Mg²⁺ in most diseases have been controversial because of conflicting findings in earlier studies. Recent clinical and preclinical studies provide novel insights into the use of Mg²⁺ for the treatment and prevention of diseases affecting different organ systems. In this review, we provide an overview of recent clinical evidence for, and controversies over, the medical benefits of Mg²⁺. In addition, we critically discuss recent advances in understanding the mechanisms of action of Mg²⁺, which could enable the development of novel targeted therapies.

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来源期刊

Trends in pharmacological sciences 医学-药学

CiteScore

23.90

自引率

0.70%

发文量

132

审稿时长

6-12 weeks

期刊介绍： Trends in Pharmacological Sciences (TIPS) is a monthly peer-reviewed reviews journal that focuses on a wide range of topics in pharmacology, pharmacy, pharmaceutics, and toxicology. Launched in 1979, TIPS publishes concise articles discussing the latest advancements in pharmacology and therapeutics research. The journal encourages submissions that align with its core themes while also being open to articles on the biopharma regulatory landscape, science policy and regulation, and bioethics. Each issue of TIPS provides a platform for experts to share their insights and perspectives on the most exciting developments in the field. Through rigorous peer review, the journal ensures the quality and reliability of published articles. Authors are invited to contribute articles that contribute to the understanding of pharmacology and its applications in various domains. Whether it's exploring innovative drug therapies or discussing the ethical considerations of pharmaceutical research, TIPS provides a valuable resource for researchers, practitioners, and policymakers in the pharmacological sciences.