小剂量糖皮质激素、霉酚酸酯和羟氯喹治疗 IgA 肾病，当前临床试验的最新进展。

IF 2.4 4区医学 Q2 UROLOGY & NEPHROLOGY

Nephrology Pub Date : 2024-09-01 Epub Date: 2024-07-18 DOI:10.1111/nep.14369

Pei Chen, Jicheng Lv

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引用次数: 0

摘要

这篇微型综述探讨了糖皮质激素、霉酚酸酯（MMF）和羟氯喹（HCQ）在 IgA 肾病（IgAN）中的应用。报告讨论了 TESTING 和 STOP-IgAN 等关键性试验中关于糖皮质激素疗效的相互矛盾的结论，强调减量方案可能是更安全的选择。MMF在不同人群中的疗效也不尽相同，在中国人群中的疗效很好，但在其他人群中的疗效尚无定论。HCQ 在减少蛋白尿方面显示出潜力，目前正在对其长期益处进行研究。

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Low dose glucocorticoids, mycophenolate mofetil and hydroxychloroquine in IgA nephropathy, an update of current clinical trials.

This mini-review explores glucocorticoids, mycophenolate mofetil (MMF), and hydroxychloroquine (HCQ) in IgA nephropathy (IgAN). It discusses conflicting findings from pivotal trials like TESTING and STOP-IgAN regarding glucocorticoid efficacy, emphasizing reduced-dose protocols as potentially safer options. MMF's effectiveness varies among populations, demonstrating promise in Chinese cohorts but yielding inconclusive results elsewhere. HCQ shows potential in reducing proteinuria, with ongoing trials investigating its long-term benefits.

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来源期刊

Nephrology 医学-泌尿学与肾脏学

CiteScore

4.50

自引率

4.00%

发文量

128

审稿时长

4-8 weeks

期刊介绍： Nephrology is published eight times per year by the Asian Pacific Society of Nephrology. It has a special emphasis on the needs of Clinical Nephrologists and those in developing countries. The journal publishes reviews and papers of international interest describing original research concerned with clinical and experimental aspects of nephrology.