脑疟疾发病机制与APOE介导的淀粉样变性之间的联系：观察与假设。

IF 4.6 2区医学 Q1 NEUROSCIENCES

Molecular Neurobiology Pub Date : 2025-02-01 Epub Date: 2024-07-18 DOI:10.1007/s12035-024-04366-3

Mwikali Kioko, Shaban Mwangi, James M Njunge, James A Berkley, Philip Bejon, Abdirahman I Abdi

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引用次数: 0

摘要

虽然大多数脑疟疾患儿都能完全康复，但超过五分之一的幸存者在出院后会出现神经发育后遗症，提示神经元损伤已进入晚期。然而，引发脑疟疾神经功能障碍的脑分子过程仍存在争议。在本文中，我们探讨了现有数据，并假设脑疟疾可能与 APOE 介导的淀粉样变性有关，而淀粉样变性是与阿尔茨海默病相关的病理过程之一。如果我们的假设得到验证并被证实，那么它将对我们所了解的脑疟疾发病机制产生深远的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Linking Cerebral Malaria Pathogenesis to APOE-Mediated Amyloidosis: Observations and Hypothesis.

Although most children with cerebral malaria fully recover, more than a fifth of the survivors develop post-discharge neurodevelopmental sequelae suggestive of advanced neuronal injury. However, the cerebral molecular processes initiating neurological dysfunction in cerebral malaria are still debatable. In this article, we explore available data and hypothesise that cerebral malaria might be linked to APOE-mediated amyloidosis, one of the pathological processes associated with Alzheimer's disease. If our hypothesis is tested and found to be true, it could have far-reaching implications for what we know about cerebral malaria pathogenesis.

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.